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Cilia arose early during eukaryotic evolution, and their structural components are highly conserved from the simplest protists to complex metazoan species. In recent years, the role of cilia in the ontogeny of vertebrate organs has received increasing attention due to a staggering correlation between human disease and dysfunctional cilia. In particular, the presence of cilia in both the developing...
Pax9 encodes a paired‐box homeodomain (Pax) transcription factor and is critical for the development of multiple organs. Using CrispR/Cas9‐mediated homologous directed repair (HDR), we generated a new Pax9‐CreER knock‐in mouse line in which the CreERT2 fusion protein is produced after synthesis of endogenous Pax9 protein. We found that tdTomato reporter expression in Pax9‐CreER;tdTomato reporter mice...
Positive transcription elongation factor b (P‐TEFb) is an RNA polymerase II kinase that phosphorylates Ser2 of the carboxyl‐terminal domain and promotes the elongation phase of transcription. Despite the fact that P‐TEFb has role in many cellular processes, the role of this kinase complex remains to be understood in early developmental events. In this study, using immunocytochemical analyses, we find...
Actin filaments and microtubules are principal components of the cytoskeleton that regulate the basic cellular phenomena underlying many fundamental cellular processes. Therefore, analyzing their dynamics in living cells is important for understanding cellular events more precisely. In this article, we report two novel transgenic zebrafish lines expressing red fluorescent proteins tagged with Lifeact...
Wnt/β‐catenin signals are important regulators of embryonic and adult stem cell self‐renewal and differentiation and play causative roles in tumorigenesis. Purified recombinant Wnt3a protein, or Wnt3a‐conditioned culture medium, has been widely used to study canonical Wnt signaling in vitro or ex vivo. To study the role of Wnt3a in embryogenesis and cancer models, we developed a Cre recombinase activatable...
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