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Mutations in the gene encoding the T‐box transcription factor TBX22 cause X‐linked cleft palate and ankyloglossia in humans. Here we show that Tbx22 expression during facial and palatal development is regulated by FGF and BMP signaling. Our results demonstrate that FGF8 induces Tbx22 in the early face while BMP4 represses and thus restricts its expression. This regulation is conserved between chicken...
Bone morphogenetic protein (BMP) signals are essential for lens development. However, the temporal requirement of BMP activity during early events of lens development has remained elusive. To investigate this question, we have used gain‐ and loss‐of‐function analyses in chick explant and intact embryo assays. Here, we show that BMP activity is both required and sufficient to induce L‐Maf expression,...
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