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Background
Allergic contact dermatitis caused by henna‐based hair‐colouring products has been associated with adulteration of henna with p‐phenylenediamine (PPD).
Objectives
To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway in order to evaluate the allergenic potential of hair‐colouring products.
Methods
The...
Background
Over 4000 small chemicals have been identified as allergens capable of inducing skin sensitization. Many sensitizers are hypothesized to act as haptens producing novel antigens, which can be presented to T cells by human leukocyte antigens (HLAs). Recent studies suggest that some chemical allergens use hapten‐independent mechanisms.
Objective
To determine whether molecular docking can...
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