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Introduction
Stenotic aortic valve disease (AS) causes pressure overload of the left ventricle (LV) that may trigger adverse remodeling and precipitate progression towards heart failure (HF). As myocardial energetics can be impaired during AS, LV wall stresses and biomechanical power provide a complementary view of LV performance that may aide in better assessing the state of disease.
Objectives...
In this work, we present a fully coupled fluid‐electro‐mechanical model of a 50th percentile human heart. The model is implemented on Alya, the BSC multi‐physics parallel code, capable of running efficiently in supercomputers. Blood in the cardiac cavities is modeled by the incompressible Navier‐Stokes equations and an arbitrary Lagrangian‐Eulerian (ALE) scheme. Electrophysiology is modeled with a...
The cover image is based on the Research Article A noninvasive method for the determination of in vivo mitral valve leaflet strains by Bruno V. Rego et al., https://doi.org/10.1002/cnm.3142.
Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at the front of the cell, close to the cell membrane, and depolymerize at the rear. The dynamic actin turnover induces the so‐called intracellular retrograde flow, and it is a fundamental...
Computational fluid dynamics (CFD) simulations of airflow in the human airways have the potential to provide a great deal of information that can aid clinicians in case management and surgical decision making, such as airway resistance, energy expenditure, airflow distribution, heat and moisture transfer, and particle deposition, as well as the change in each of these due to surgical interventions...
Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and surgical planning applications for treatment of MV disease. Yet, to date, there are no accepted noninvasive methods for determination of MV leaflet deformation, which is a critical metric of MV function. In this study, we present a novel, completely noninvasive computational method to estimate MV leaflet in‐plane...
The present work analyses the performance of four glaucoma drainage devices, by means of a novel patient‐oriented numerical procedure. The procedure is based on the three‐dimensional geometry reconstruction from the stacks of tomographic images of a human eye, at different angles, on meshing and on thermo‐fluid dynamics modelling activities, carried out on the reconstructed computational domain. The...
In computational fluid dynamics, there is a high interest in modeling flow diverter stents as porous media due to its reduced computational loads. One of the main difficulties of such models is proper parameter setup. Most authors assume flow diverter's wire screen as an isotropic and homogeneous medium, while others proposes anisotropic configurations, yet very little is discussed about the effect...
Models for cardiac mechanics require an activation mechanism properly representing the stress‐strain relations in the contracting myocardium. In this paper, we propose a new activation model that accounts for the transmural heterogeneities observed in myocardial strain measurements. In order to take the anisotropy of the active mechanics into account, our model is based on an active strain formulation...
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