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This study develops a computational model of the braided stent for interpreting the mechanism of stent flattening during deployment into curved arteries. Stent wires are expressed using Kirchhoff's rod theory and their mechanical behavior is treated using a corotational beam formulation. The equation of motion of the braided stent is solved in a step‐by‐step manner using the resultant elastic force...
Performance of the locking compression plate (LCP) is a multifactorial function. The control parameters of plating, such as geometries, material properties, and physical constraints of the LCP components, affect basic functions associated with the bone fixation, including the extent of stress shielding and subsequent bone remodeling, strength and stability of the bone‐LCP construct, and performance...
We use computational fluid dynamics (CFD) to simulate blood flow in intracranial aneurysms (IAs). Despite ongoing improvements in the accuracy and efficiency of body‐fitted CFD solvers, generation of a high quality mesh appears as the bottleneck of the flow simulation and strongly affects the accuracy of the numerical solution. To overcome this drawback, we use an immersed boundary method. The proposed...
We report a novel mathematical model of an artificial auditory system consisting of a micro‐machined cochlea and the auditory nerve response it evokes. The modeled micro‐machined cochlea is one previously realized experimentally by mimicking functions of the cochlea [Shintaku et al, Sens. Actuat. 158 (2010) 183–192; Inaoka et al, Proc. Natl. Acad. Sci. USA 108 (2011) 18390–18395]. First, from the...
The contraction of the human heart is a complex process as a consequence of the interaction of internal and external forces. In current clinical routine, the resulting deformation can be imaged during an entire heart beat. However, the active tension development cannot be measured in vivo but may provide valuable diagnostic information. In this work, we present a novel numerical method for solving...
Recent experimental observations have shown evidence of an unexpected sudden drop‐off in the dense core vesicles (DCVs) content at the ends of certain types of axon endings. This article seeks to determine whether these observations may be explained without modifying the parameters characterizing the ability of distal en passant boutons to capture and accumulate DCVs. We developed a mathematical model...
The cover image is based on the Special Issue Article Uncertainty quantification in subject‐specific estimation of local vessel mechanical properties by Bruno V. Rego et al., https://doi.org/10.1002/cnm.3535.
Quantitative estimation of local mechanical properties remains critically important in the ongoing effort to elucidate how blood vessels establish, maintain, or lose mechanical homeostasis. Recent advances based on panoramic digital image correlation (pDIC) have made high‐fidelity 3D reconstructions of small‐animal (e.g., murine) vessels possible when imaged in a variety of quasi‐statically loaded...
Patients with pulsatile tinnitus (PT) have unstable treatment effects after resurfacing surgery. Flow‐diverting stents (FDS) are proposed as a potential method for the treatment of PT, but the therapeutic effect is not clear. This study aimed to investigate the efficacy of FDS in the treatment of patients with PT induced by sigmoid sinus diverticulum (SSD) and sigmoid sinus wall dehiscence (SSWD)...
Endovascular aortic repair (EVAR) has become the preferred intervention option for aortic aneurysms and dissections. This is because EVAR is much less invasive than the alternative open surgery repair. While in‐hospital mortality rates are smaller for EVAR than open repair (1%–2% vs. 3%–5%), the early benefits of EVAR are lost after 3 years due to larger rates of complications in the EVAR group. Clinicians...
Cells are a fundamental structural, functional and biological unit for all living organisms. Up till now, considerable efforts have been made to study the responses of single cells and subcellular components to an external load, and understand the biophysics underlying cell rheology, mechanotransduction and cell functions using experimental and in silico approaches. In the last decade, computational...
Computational Fluid Dynamics (CFD) and time‐resolved phase‐contrast magnetic resonance imaging (PC‐MRI) are potential non‐invasive methods for the assessment of the severity of arterial stenoses. Fractional flow reserve (FFR) is the current “gold standard” for determining stenosis severity in the coronary arteries but is an invasive method requiring insertion of a pressure wire. CFD derived FFR (vFFR)...
Coronary artery bypass grafts (CABG) surgery is an invasive procedure performed to circumvent partial or complete blood flow blockage in coronary artery disease. In this work, we apply a numerical optimal flow control model to patient‐specific geometries of CABG, reconstructed from clinical images of real‐life surgical cases, in parameterized settings. The aim of these applications is to match known...
Recently, a significant way to diagnose the disease is using the model of medical data mining. The most challenging task in the healthcare field is to face a large amount of data during disease analyzes and prediction. Once the data are transformed into valuable data by means of data mining models then the actual prediction and decision making is easier. The existing studies met few shortcomings because...
Knowledge of skeletal muscle fiber orientations is important for modeling mechanical properties and behavior of muscle tissue. Diffusion tensor imaging (DTI) may be used to define fiber architecture in vivo but can be expensive and time‐consuming and thus impractical for biomechanical modeling applications. Muscle tractography using computational fluid dynamics (CFD) has been shown to determine muscle...
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