The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
We propose a hemodynamic reduced‐order model bridging macroscopic and mesoscopic blood flow circulation scales from arteries to capillaries. In silico tree‐like vascular geometries, mathematically described by graphs, are synthetically generated by means of stochastic growth algorithms constrained by statistical morphological and topological principles. Scale‐specific pruning gradation of the tree...
The subendothelial matrix of the artery is a complex mechanical environment where endothelial cells respond to and affect changes upon the underlying substrate. Our recent work has demonstrated that endothelial cell strain heterogeneity increases on a more heterogeneous underlying subendothelial matrix, and these cells display increased focal adhesion presence on stiffer substrate areas. However,...
Tortuous vessels are often observed in vivo and could hinder or even disrupt blood flow to distal organs. Besides genetic and biological factors, the in vivo mechanical loading seems to play a role in the formation of tortuous vessels, but the mechanism for formation of helical vessel shape remains unclear. Accordingly, the aim of this study was to investigate the biomechanical loads that trigger...
Areas of disturbed shear that develop following arteriovenous fistula (AVF) creation are believed to trigger the onset of intimal hyperplasia (IH), leading to AVF dysfunction. The presence of helical flow can suppress the flow disturbances that lead to disturbed shear in other areas of the vasculature. However, the relationship between helical flow and disturbed shear remains unevaluated in AVF. In...
We derive a variational multiscale (VMS) finite element formulation for a viscoelastic, tensor‐based blood damage model. The tensor equation is numerically stabilized by a logarithmic shape tensor description that prevents unphysical, negative eigenvalues. The resulting VMS stabilization terms for this so‐called log‐morph equation are presented together with their special numerical treatment. Results...
This work uses high‐order discontinuous Galerkin discretization techniques to simulate transitional and turbulent flows through medical devices. Flows through medical devices are characterized by moderate Reynolds numbers and typically involve different flow regimes such as laminar, transitional, and turbulent flows. Previous studies for the FDA benchmark nozzle model revealed limitations of Reynolds‐averaged...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.