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Epithelial tissues show a particular topology where cells resemble a polygon‐like shape, but some biological processes can alter this tissue topology. During cell proliferation, mitotic cell dilation deforms the tissue and modifies the tissue topology. Additionally, cells are reorganized in the epithelial layer and these rearrangements also alter the polygon distribution.
We present here a computer‐based...
The aim of this study is to model the computational model of seated whole human body including skeleton, muscle, viscera, ligament, intervertebral disc, and skin to predict effect of the factors (sitting postures, muscle and skin, buttocks, viscera, arms, gravity, and boundary conditions) on the biodynamic characteristics of spine. Two finite element models of seated whole body and a large number...
Computational models of the heart have reached a maturity level that render them useful for in silico studies of arrhythmia and other cardiac diseases. However, the translation to the clinic of cardiac simulations critically depends on demonstrating the accuracy, robustness, and reliability of the underlying computational models under the presence of uncertainties. In this work, we study for the first...
Liver radioembolization is a promising treatment option for combating liver tumors. It is performed by placing a microcatheter in the hepatic artery and administering radiation‐emitting microspheres through the arterial bloodstream so that they get lodged in the tumoral bed. In avoiding nontarget radiation, the standard practice is to conduct a pretreatment, in which the microcatheter location and...
Chronic scapholunate ligament (SL) injury is a common disorder affecting the wrist. Despite advances in surgical techniques used to treat this injury, SL gap re‐emergence may occur postoperatively. This paper presents an investigation into the performance of the Corella, schapolunate axis (SLAM), and modified Brunelli tenodesis (MBT) surgical reconstruction techniques used to treat scapholunate instability...
The immersed boundary method is an approach to fluid‐structure interaction that uses a Lagrangian description of the structural deformations, stresses, and forces along with an Eulerian description of the momentum, viscosity, and incompressibility of the fluid‐structure system. The original immersed boundary methods described immersed elastic structures using systems of flexible fibers, and even now,...
Abdominal aortic aneurysms (AAAs) typically harbour an intraluminal thrombus (ILT), yet most prior computational models neglect biochemomechanical effects of thrombus on lesion evolution. We recently proposed a growth and remodelling model of thrombus‐laden AAAs that introduced a number of new constitutive relations and associated model parameters. Because values of several of these parameters have...
The morphology of endothelial cells (ECs) may be an indication for determining atheroprone sites. Until now, there has been no clinical imaging technique to visualize the morphology of ECs in the arteries. The present study introduces a computational technique for determining the morphology of ECs. This technique is a multiscale simulation consisting of the artery scale and the cell scale. The artery...
The paper presents an applied methodology for numerical finite element analysis of coronary stent crimping and the free inflation process with the use of a folded noncompliant angioplasty balloon. The use of an implicit scheme is considered as the most original part of the work, as an explicit finite element procedure is very often preferred. Hitherto, when the implicit solution was used for the finite...
Effective sparse representation of X‐ray medical images within the context of data reduction is considered. The proposed framework is shown to render an enormous reduction in the cardinality of the data set required to represent this class of images at very good quality. The goal is achieved by (1) creating a dictionary of suitable elements for the image decomposition in the wavelet domain and (2)...
Vaginal delivery is commonly accepted as a risk factor in pelvic floor dysfunction; however, other obstetric procedures (episiotomy) are still controversial. In this work, to analyze the relationship between episiotomy and pelvic floor function, a finite element model of the pelvic cavity is used considering the pelvic floor muscles (PFMs) with damaged regions from spontaneous vaginal delivery and...
Blast‐induced traumatic brain injury has been on the rise in recent years because of the increasing use of improvised explosive devices in conflict zones. Our study investigates the response of a helmeted human head subjected to a blast of 1 atm peak overpressure, for cases with and without a standard polycarbonate (PC) face shield and for face shields comprising of composite PC and aerogel materials...
Dynamic load exists in numerous biomechanical systems, and its identification signifies a critical issue for characterizing dynamic behaviors and studying biomechanical consequence of the systems. This study aims to identify dynamic load in the dental prosthetic structures, namely, 3‐unit implant‐supported fixed partial denture (I‐FPD) and teeth‐supported fixed partial denture. The 3‐dimensional finite...
One‐dimensional models of the cardiovascular system can capture the physics of pulse waves but involve many parameters. Since these may vary among individuals, patient‐specific models are difficult to construct. Sensitivity analysis can be used to rank model parameters by their effect on outputs and to quantify how uncertainty in parameters influences output uncertainty. This type of analysis is often...
A new retinal reattachment surgical procedure is based on a stent that is deployed to press the retina back in place. An eye‐stent finite element model studied the strain induced by the stent on retina. Finite element model simulations were performed for several stent geometric configurations (number of loops, wire diameter, and intraocular pressure). The finite element model was validated against...
The MRI‐based computational model, previously validated by tagged MRI and harmonic phase imaging analysis technique on in vivo human brain deformation, is used to study transient wave dynamics during blunt head trauma. Three different constitutive models are used for the cerebrospinal fluid: incompressible solid elastic, viscoelastic, and fluid‐like elastic using an equation of state model. Three...
The voxel finite cell method uses unfitted finite element meshes and voxel quadrature rules to seamlessly transfer computed tomography data into patient‐specific bone discretizations. The method, however, still requires the explicit parametrization of boundary surfaces to impose traction and displacement boundary conditions, which constitutes a potential roadblock to automation. We explore a phase‐field–based...
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