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In silico, medicine models are frequently used to represent a phenomenon across multiples space–time scales. Most of these multiscale models require impracticable execution times to be solved, even using high performance computing systems, because typically each representative volume element in the upper scale model is coupled to an instance of the lower scale model; this causes a combinatory explosion...
This study investigated the effects of cardiac properties variability on arterial pulse wave morphology using blood flow modelling and pulse wave analysis. A lumped‐parameter model of the left part of the heart was coupled to a one‐dimensional model of the arterial network and validated using reference pulse waveforms in turn verified by comparison with in vivo measurements. A sensitivity analysis...
We propose an innovative statistical‐numerical method to model spatio‐temporal data, observed over a generic two‐dimensional Riemanian manifold. The proposed approach consists of a regression model completed with a regularizing term based on the heat equation. The model is discretized through a finite element scheme set on the manifold, and solved by resorting to a fixed point‐based iterative algorithm...
This work intends to study the effect of aortic annulus eccentricity and leaflet rigidity on the performance, thrombogenic risk and calcification risk in bioprosthetic aortic valve replacements (BAVRs). To address these questions, a two‐way immersed fluid–structure interaction (FSI) computational model was implemented in a high‐performance computing (HPC) multi‐physics simulation software, and validated...
Muscle contraction is triggered by the activation of the actin sites of the thin filament by calcium ions. It results that the thin filament activation level varies over time. Moreover, this activation process is also used as a regulation mechanism of the developed force. Our objective is to build a model of varying actin site activation level within the classical Huxley'57 two‐state framework. This...
Unlocking the biomechanical effects of cervical spine positioning rotation manipulation in the treatment of patients with neck pain. In this paper, the safety of the cervical positioning rotation manipulation is analyzed by experimentally obtaining head kinematic data, importing them into a finite element model that has been developed and validated, and calculating and analyzing the angular displacements,...
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