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Hymenopteran eusociality has been proposed to be associated with the activity of the transcription factor CREB (cAMP‐response element binding protein). The honeybee (Apis mellifera) is a eusocial insect displaying a pronounced age‐dependent division of labor. In honeybee brains, CREB‐dependent genes are regulated in an age‐dependent manner, indicating that there might be a role for neuronal honeybee...
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