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BACKGROUND:Male urethral cancer is a rare neoplasm, with the published literature consisting of small single‐institution retrospective series. As such, there is no objective analysis of prognostic factors and treatment outcome. The author sought to use the population‐based Surveillance, Epidemiology, and End Results (SEER) database to evaluate prognostic factors in male urethral cancer.
METHODS:From...
BACKGROUND:Definitive local therapy of early stage breast cancer includes adjuvant radiotherapy after breast‐conserving surgery (BCS). The authors analyzed factors that influence the receipt of radiotherapy therapy and their resultant impact on outcome.
METHODS:Using data from the Kentucky Cancer Registry, the authors analyzed the rate of adjuvant radiotherapy for 11,914 women who underwent BCS as...
BACKGROUND:The purpose of this study was to assess the efficacy and safety of 5‐fluorouracil (5FU) and gemcitabine administered concurrently with radiation in patients with locally advanced, nonmetastatic pancreatic cancer.
METHODS:Eligible patients had histologically confirmed pancreatic adenocarcinoma deemed locally unresectable without evidence of metastatic disease. In addition, all patients...
BACKGROUND:Stereotactic body radiotherapy for previously irradiated, progressive spinal metastases may be a viable option in selected patients. The authors review a prospective series of spinal metastasis patients reirradiated with stereotactic body radiotherapy.
METHODS:A total of 59 patients with 63 tumors of the spine were reirradiated with stereotactic body radiotherapy between 2003 and 2009...
BACKGROUND:In 2002, the US Food and Drug Administration approved an implantable balloon catheter that delivers accelerated partial breast irradiation (APBI) after breast‐conserving surgery (BCS). The objective of the current study was to determine the use of implantable APBI (IAPBI) in the United States and factors associated with IAPBI use.
METHODS:By using the Surveillance, Epidemiology, and End...
BACKGROUND:Although pilocytic astrocytoma accounts for up to 40% of all childhood brain tumors, it is a rare disease in adults. Consequently, there are few mature data on the impact of up‐front treatment options after surgery that include observation or adjuvant radiotherapy.
METHODS:Ten women and 20 men were identified who were diagnosed with pilocytic astrocytoma from 1971 to 2007 and were retrospectively...
BACKGROUND:The objective of this study was to review the outcome of patients with solitary plasmacytoma (SP) after definitive radiation therapy.
METHODS:The authors retrospectively reviewed 84 patients with SP who were diagnosed and treated at The University of Texas MD Anderson Cancer Center during 1988 to 2008. The impact of tumor anatomic site, tumor size, and the presence of serum and urinary...
The authors undertook a systematic review to designate the role that radiotherapy (RT) might play in the treatment of retroperitoneal sarcomas. Correlating with recent literature, the objective of this review was to evaluate whether there was enough evidence for the authors to develop an institutional treatment protocol concerning the use of RT in the treatment of retroperitoneal sarcoma. Furthermore,...
BACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long‐term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivation therapy (ADT) for intermediate‐risk prostate cancer are presented.
METHODS:Intermediate‐risk...
BACKGROUND:The authors previously identified racial/ethnic disparities in the use of radiation therapy (RT) in patients with advanced breast cancer (BC). They hypothesized that disparities in the use of RT were associated with survival differences favoring white patients.
METHODS:The authors used the Surveillance, Epidemiology, and End Results database to identify white, black, Hispanic, and Asian...
BACKGROUND:The reported high rate of local recurrence (LR) in myxofibrosarcoma raises the question of whether this sarcoma histology should be considered radioresistant. In this study, the authors compared rates and patterns of LR of high‐grade (HG) myxofibrosarcoma with rates and patterns of HG leiomyosarcoma, which was chosen because of the similarity in incidence and general treatment approach...
BACKGROUND:Mutations in the tumor protein 53 (TP53) tumor suppressor gene are common in head and neck squamous cell carcinoma (HNSCC) and correlate with radioresistance. Currently, there are no clinically available therapeutic approaches targeting p53 in HNSCC. In this report, the authors propose a strategy that uses TP53 mutational status to individualize antimetabolic strategies for the potentiation...
BACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population‐based study has not been evaluated to date.
METHODS:The authors analyzed all patients who had localized and/or regional glottic and supraglottic cancer in the Surveillance, Epidemiology, and...
BACKGROUND:Salvage stereotactic radiosurgery (SRS) is often considered in breast cancer patients previously treated for brain metastases. The goal of this study was to analyze clinical outcomes and prognostic factors for survival in the salvage setting.
METHODS:The authors retrospectively examined 79 consecutive breast cancer patients who received salvage SRS (interval of >3 months after initial...
BACKGROUND:Radiation therapy (RT) after breast‐conserving surgery (BCS) is associated with a significant reduction in ipsilateral breast tumor recurrence and breast cancer mortality rates in patients with early stage breast cancer. The authors of this report sought to determine which patients with breast cancer do not receive RT after BCS in the United States.
METHODS:The Surveillance, Epidemiology,...
BACKGROUND:Breast reconstruction with tissue expander (TE)/permanent implant (PI) followed by postmastectomy radiation (PMRT) is an increasingly popular treatment for breast cancer patients. The long‐term rates of permanent implant removal or replacement (PIRR) and clinical outcomes in patients treated with a uniform reconstructive surgery and radiation regimen were evaluated.
METHODS:Between 1996...
BACKGROUND:Very few published studies have dealt with the management of locally advanced cervix carcinoma among human immunodeficiency virus (HIV)‐positive patients. The objective of this study was to compare the clinical characteristics, radiation and chemotherapy treatments, and outcomes in a cohort of HIV‐positive and HIV‐negative women with cervical cancer.
METHODS:The authors reviewed the charts...
BACKGROUND:Cervical cancer is common in the elderly. The authors examined the patterns of care, treatment, and outcomes of elderly women with cervical cancer.
METHODS:Women with cervical cancer diagnosed between 1988 and 2005 and registered in the Surveillance, Epidemiology, and End Results database were analyzed. Patients were stratified by age: <50, 50 to 59, 60 to 69, 70 to 79, and ≥80 years...
BACKGROUND.The role of radiotherapy (RT) in the management of Merkel cell carcinoma (MCC) is controversial. The authors of this report evaluated the rates and patterns of failure in a selected group of patients who underwent RT for MCC of the head and neck (HN).
METHODS.The records of 145 consecutive patients with MCC of the HN who presented to the authors' institution between 1988 and 2009 were...
BACKGROUND:In this phase 2 component of a multi‐institutional, phase 2/3, randomized trial, the authors assessed the feasibility and preliminary efficacy of acupuncture‐like transcutaneous electrical nerve stimulation (ALTENS) in reducing radiation‐induced xerostomia.
METHODS:Patients with cancer of the head and neck who were 3 to 24 months from completing radiotherapy with or without chemotherapy...
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