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BACKGROUNDThe current study was performed to identify risk factors for a lower quality of life (QOL) among low‐income women with breast cancer (BC), with an emphasis on the impact of patient‐physician communication. In addition, ethnic/racial group differences in QOL changes over time were examined.
METHODSA longitudinal study was conducted among 921 low‐income women with BC. Patients were interviewed...
BACKGROUNDBiochemical failure (BF) after radiation therapy is defined on the basis of a rising prostate‐specific antigen (PSA) level (A1 failure) or any event that prompts the initiation of salvage androgen‐deprivation therapy without PSA failure (A2). It was hypothesized that A2 failure may have a different prognosis.
METHODSData for 2799 eligible patients from Radiation Therapy Oncology Group (RTOG)...
BACKGROUNDProvider‐based research networks such as the National Cancer Institute's Community Clinical Oncology Program (CCOP) have been shown to facilitate the translation of evidence‐based cancer care into clinical practice. This study compared the utilization of laparoscopy and partial nephrectomy among patients with early‐stage kidney cancer according to their exposure to CCOP‐affiliated providers...
BACKGROUNDVascular endothelial growth factor (VEGF)–mediated angiogenesis plays an important role in non–small cell lung cancer (NSCLC). Ramucirumab is a human immunoglobulin G1 monoclonal antibody that inhibits VEGF receptor 2. This phase 2 study investigated ramucirumab in combination with first‐line pemetrexed and platinum chemotherapy in advanced/metastatic NSCLC.
METHODSEligible stage IV nonsquamous...
The authors review methods for image‐guided diagnosis and therapy that increase precision in the detection, characterization, and localization of many forms of cancer to achieve optimal target definition and complete resection or ablation. A new model of translational, clinical, image‐guided therapy research is presented, and the Advanced Multimodality Image‐Guided Operating (AMIGO) suite is described...
Advances in clinical medicine require effective translational research. Ideally, this research will be performed by multidisciplinary teams that include both physicians and basic scientists. However, the current system does not appropriately train either physicians or basic scientists for these careers. In addition, translational researchers are often not properly rewarded, and this creates a disincentive...
BACKGROUNDWe conducted a study to investigate the impact of hospitalization for hematopoietic stem cell transplantation (HCT) on the quality of life (QOL) and mood of patients and family caregivers (FC).
METHODSWe conducted a longitudinal study of patients who were hospitalized for HCT and their FC. We assessed QOL (using the Functional Assessment of Cancer Therapy‐Bone Marrow Transplantation) and...
BACKGROUNDThe hypomethylating agents (HMAs) azacitidine and decitabine are most commonly used to treat patients with higher‐risk myelodysplastic syndromes (MDS). To the authors' knowledge, the prognosis of patients with low‐risk and intermediate‐1–risk MDS by the International Prognostic Scoring System (IPSS) after HMA failure has not been explored comprehensively.
METHODSThe clinical characteristics...
BACKGROUNDYoung adult female cancer survivors have unmet reproductive concerns and informational needs that are associated with poorer quality of life. The purpose of this study was to examine the association between current reproductive concerns and moderate to severe depression among young survivors.
METHODSThis cross‐sectional study included 200 female cancer survivors between the ages of 18 and...
BACKGROUNDCancer survivors' disclosure of complementary health approaches (CHAs) to their follow‐up care physicians is necessary to ensure the safe and optimal use of such approaches. Rates of disclosure of CHAs are variable and may be facilitated by patient‐centered communication.
METHODSThis cross‐sectional study conducted in 2003‐2004 examined a population‐based sample of leukemia, colorectal,...
BACKGROUNDSupportive oncology practice can be enhanced by the integration of a brief and validated electronic patient‐reported outcome assessment into the electronic health record (EHR) and clinical workflow.
METHODSSix hundred thirty‐six women receiving gynecologic oncology outpatient care received instructions to complete clinical assessments through Epic MyChart, an EHR patient communication portal...
BACKGROUNDData on health‐related quality of life (HRQoL) changes among Americans aged ≥65 following colorectal cancer (CRC) diagnosis and treatment are limited. This study compared HRQoL changes among CRC patients across stages from before to after diagnosis with matched noncancer controls.
METHODSThis population‐based study used the Surveillance, Epidemiology, and End Results Medicare Health Outcomes...
BACKGROUNDResearch has demonstrated that communication and care coordination improve cancer patient outcomes. To improve communication and care coordination, it is important to understand primary care providers' (PCPs') perceptions of communication with oncologists as well as PCPs' communication needs.
METHODSA mixed‐methods approach was used in the present study. In the qualitative phase of the...
BACKGROUNDPrevious reports have described differences in biology and outcome for colorectal cancer based on whether the primary is right or left sided. Further division by right, left, and rectum or even exact primary site has also been explored. Possible differences in response to biological agents have also been reported based on side of primary lesion.
METHODSWe explored the South Australian registry...
BACKGROUNDFlow cytometry (FC) is a commonly requested test in the workup of leukocytosis in community practices. The role of FC in chronic‐phase chronic myeloid leukemia (CP‐CML) is unknown. We hypothesized that finding aberrant cells with FC in CP‐CML may predict early blast‐phase (BP) transformation.
METHODSResults for FC performed at the time of diagnosis for adult and pediatric patients with...
BACKGROUNDThe categories of the International Myeloma Working Group (IMWG) response criteria for multiple myeloma are based on the magnitude of the change in paraprotein and the normalization of the free light chain ratio (rFLC). However, the relationship between the response by these biomarkers and clinical outcomes has not been validated with novel compounds in the phase 1 setting. Early response...
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