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Background
Strategies using oral arsenic trioxide (As2O3) are efficacious in relapsed acute promyelocytic leukemia (APL), but they have not been examined in newly diagnosed cases.
Methods
Sixty‐two consecutive patients (24 men and 38 women) with a median age of 52 years (range, 22‐85 years), 36% of whom had high‐risk features, underwent induction with all‐trans retinoic acid at 45 mg/m2/d, oral...
Background
The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial assessed the effect of screening with prostate‐specific antigen and a digital rectal examination on prostate cancer mortality. Another endpoint of interest was the burden of total metastatic disease.
Methods
All men in PLCO were assessed for metastatic prostate cancer at diagnosis; men with clinical stage I/II...
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