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The clinical‐pathological features of inflammatory breast cancer include enrichment of factors that have been previously associated with radioresistant disease, including negative hormone receptor status and a phenotype enriched for relatively radioresistant breast cancer stem/progenitor cells. The risks and benefits of accelerated postmastectomy radiation treatment regimens in the multimodality management...
BACKGROUND:Localized prostate cancer can be treated several different ways, but head‐to‐head comparisons of treatments are infrequent. The authors of this report conducted a randomized, unblinded, noninferiority trial to compare cryoablation with external beam radiotherapy in these patients.
METHODS:From December 1997 through February 2003, 244 men with newly diagnosed localized prostate cancer were...
Shortly after the onset of the acquired immunodeficiency syndrome (AIDS) epidemic in the 1980s, reports of radiation‐associated toxicity in patients with the human immunodeficiency virus (HIV) and AIDS began to appear in the medical literature. Although the majority of reports have focused on AIDS‐defining malignancies such as Kaposi sarcoma, greater‐than‐expected toxicity after a course of radiotherapy...
BACKGROUND.The authors compared the types of treatments prostate cancer patients received from county hospitals and private providers as part of a statewide public assistance program.
METHODS.This was a cohort study of 559 men enrolled in a state‐funded program for low‐income patients known as Improving Access, Counseling, and Treatment for Californians With Prostate Cancer (IMPACT). Multinomial...
BACKGROUND:The objective of the current study was to formulate a scoring system to enable decision making for prophylactic stabilization of the femur after surgical resection of a soft tissue sarcoma (STS) of the thigh.
METHODS:A logistic regression model was developed using patient variables collected from a prospectively collected database. The study group included 22 patients who developed a radiation‐related...
BACKGROUND:Radiation exposure is an established cause of clinical thyroid cancer, but little is known about radiation effects on papillary microcarcinoma (PMC) of the thyroid, a relatively common subclinical thyroid malignancy. Because the incidence of these small thyroid cancers has been increasing, it is important to better understand them and their relation to radiation.
METHODS:PMCs were identified...
BACKGROUND:Sinonasal mucosal melanoma is a rare disease associated with a very poor prognosis. Because most of the series extend retrospectively several decades, we sought to determine prognostic factors and outcomes with recent treatment modalities.
METHODS:A retrospective chart review of 58 patients treated for sinonasal melanoma at a tertiary cancer center between 1993 and 2004. The patients were...
BACKGROUND:Although several studies had examined secondary malignancies in patients with specific primary tumor types, to the authors' knowledge there are very few data examining the long‐term sequelae of pelvic radiation as a whole. The goal of the current study was to examine the risk of treatment‐associated leukemia and multiple myeloma in patients treated with pelvic radiotherapy.
METHODS:Patients...
BACKGROUND:The objective of this study was to identify measurable parameters that provide quality data for assessing how well cancer care adheres to accepted treatment guidelines and is delivered to any given patient with oral tongue cancer.
METHODS:A retrospective chart review included 116 patients treated for T1‐T2/N0‐N1 squamous cell carcinoma (SCC) of the oral tongue between 1998 and 2003. A...
BACKGROUND:Data on patients who received breast‐conserving therapy (BCT) for early stage breast cancer were examined to detect differences in disease presentation, management techniques, long‐term treatment outcomes, and toxicities based on race.
METHODS:Six hundred ninety‐nine women with breast cancer (39 African‐American [AA] women and 660 Caucasian [C] women) who received BCT were analyzed on...
BACKGROUND:Breast cancer in men is rare, so clinical trials are not practical. Recommendations suggest treating men who are diagnosed with breast cancer using the guidelines for postmenopausal women; however, to date, no population‐based studies have evaluated patterns of care.
METHODS:To examine characteristics, treatment, and survival among men with newly diagnosed breast cancer, in 2003 and 2004,...
BACKGROUND:Esophagectomy for locally advanced esophageal cancer (LAEC) is associated with limited survival. Trimodality therapy yields a small survival advantage, with cisplatin and 5‐fluorouracil regimens most frequently studied. Newer regimens may impact these poor outcomes. This phase 2 trial assessed the feasibility and efficacy of induction chemoradiotherapy with cisplatin and irinotecan followed...
BACKGROUND:The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This is a report of long‐term (≥5 years) follow‐up in patients with high‐grade, high‐risk soft tissue sarcomas treated with neoadjuvant chemotherapy, preoperative radiotherapy (RT), and adjuvant chemotherapy.
METHODS:Patients with high‐grade soft tissue sarcoma ≥8 cm in diameter of the extremities...
BACKGROUND:Approximately 50% of all patients with primary central nervous system lymphoma (PCNSL) are aged ≥65 years; however, this group is relatively understudied, and to the authors's knowledge, optimal treatment for older patients is not well defined.
METHODS:This was a retrospective review of PCNSL patients aged ≥65 years who were treated at Memorial Sloan‐Kettering Cancer Center between 1986...
BACKGROUND:The American Society for Radiation Oncology (ASTRO) consensus statement (CS) for the application of accelerated partial breast irradiation (APBI) was applied to patients who were treated with this technique on the American Society of Breast Surgeons MammoSite Registry Trial to determine potential differences in clinical outcome based on classification group.
METHODS:Patients were classified...
BACKGROUND:Because no adequate randomized trials have compared active treatment modalities for localized prostate cancer, the authors analyzed risk‐adjusted, cancer‐specific mortality outcomes among men who underwent radical prostatectomy, men who received external‐beam radiation therapy, and men who received primary androgen‐deprivation therapy.
METHODS:The Cancer of the Prostate Strategic Urologic...
BACKGROUND:The Surveillance, Epidemiology, and End Results database was analyzed to explore the pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy as well as the use of adjuvant radiation in this population.
METHODS:Identified were patients from 2004 to 2006 with clinically staged T1c‐2cNx‐0M0 prostate adenocarcinoma who underwent radical prostatectomy...
BACKGROUND:The purpose of this study was to determine the ipsilateral breast tumor recurrence (IBTR) in ductal carcinoma in situ (DCIS) patients treated in the American Society of Breast Surgeons MammoSite Breast Brachytherapy Registry Trial who met the criteria for E5194 treated with local excision and adjuvant accelerated partial breast irradiation (APBI).
METHODS:A total of 194 patients with DCIS...
BACKGROUND:Despite advancement in therapies, overall survival rates for relapsed pediatric sarcomas are dismal. Newer therapies are needed to effectively salvage these patients. Oncolytic viruses (such as reovirus) and other genetically altered viruses (such as herpes simplex viruses and adenoviruses) have shown efficacy in a variety of solid tumors including sarcomas. Reolysin is an unmodified oncolytic...
BACKGROUND:A study was undertaken to examine the patterns of systemic therapy use in conjunction with radiation therapy for patients with locally advanced head and neck squamous cell cancer.
METHODS:Between December 1, 2005 and May 11, 2009, 2874 patients with newly diagnosed head and neck squamous cell cancer who were scheduled to receive radiotherapy and/or drug therapy were registered in a prospective...
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