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BACKGROUND:Patients who are facing life‐threatening and life‐limiting cancer almost invariably experience psychological distress. Responding effectively requires therapeutic sensitivity and skill. In this study, we examined therapeutic effectiveness within the setting of cancer‐related distress with the objective of understanding its constituent parts.
METHODS:Seventy‐eight experienced psychosocial...
BACKGROUND:Breast cancer occurs rarely in men. To the authors' knowledge, no population‐based estimates of the incidence of human epidermal growth factor receptor 2 (HER2)‐positive breast cancer or of the distribution of breast cancer subtypes among male breast cancer patients have been published to date. Therefore, the objective of the current study was to explore breast tumor subtype distribution...
BACKGROUND:In this study, the authors examined the effectiveness of an online support system (Comprehensive Health Enhancement Support System [CHESS]) versus the Internet in relieving physical symptom distress in patients with non–small cell lung cancer (NSCLC).
METHODS:In total, 285 informal caregiver‐patient dyads were assigned randomly to receive, for up to 25 months, standard care plus training...
BACKGROUND:Intraoperative radiation therapy (IORT) allows delivery of high‐dose radiation at the time of lumpectomy, potentially sparing adjuvant daily radiation. A phase 2 study of pre‐excision IORT was performed for early‐stage breast cancer.
METHODS:Patients ≥ 48 years of age with invasive ductal carcinoma, ≤ 3 cm, and clinically node‐negative were eligible for this study, which was approved by...
BACKGROUND:The management of relapsed aggressive lymphomas remains problematic. Ixabepilone (BMS‐247550, epothilone B analog), a potent inhibitor of tubulin disassembly, has promising preclinical and early‐phase clinical activity in drug‐resistant malignancies.
METHODS:This multicenter phase 2 clinical trial tested the activity and safety of ixabepilone in relapsed/refractory aggressive lymphoma...
BACKGROUND:A family history of breast cancer has been shown to affect psychosocial functioning. However, the majority of research has focused on the daughters of patients with breast cancer and families with multiple relatives with the disease. The purpose of the current study was to examine cancer‐related distress and breast cancer risk perception, and further examine the predictors of these outcomes,...
BACKGROUND:In postmarketing surveillance, the US Food and Drug Administration has reported the development of lung masses, thyroid cancer, and skin cancer after amiodarone therapy.
METHODS:Using the Taiwan National Health Insurance Research database, the authors conducted a population‐based cohort study. Patients who were treated with amiodarone between 1997 and 2008 were enrolled. Those with antecedent...
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