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BACKGROUND:Poor expression of microRNAs (miRs) reportedly plays an important role in gastric carcinogenesis. Large‐scale microarray assays have indicated that there is significant down‐regulation of miR‐218 in gastric cancer. miR‐218 also was decreased specifically in human papillomavirus‐positive cell lines, cervical lesions, and cervical cancer tissues and in bronchial airway epithelium in smokers...
BACKGROUND:Docetaxel, cisplatin, and 5‐flurouracil (DCF) administered every 3 weeks produces a high rate of treatment‐related adverse events. The objective of the current study was to evaluate the efficacy and tolerability of a weekly formulation of DCF.
METHODS:Data from 117 patients treated at The University of Texas M. D. Anderson Cancer Center from 2002 to 2006 with a weekly formulation of DCF...
BACKGROUND:Health‐related quality of life (HRQoL) is a key issue in patients with metastatic esophagogastric cancer, a disease associated with survival times rarely exceeding 10 months. The objective of the current review was to evaluate the effects of chemotherapy on the HRQoL of patients with metastatic or locally advanced, inoperable esophagogastric cancer.
METHODS:A systematic MEDLINE search...
BACKGROUND:Log odds of positive lymph nodes (LODDS) is defined as the log of the ratio between the probability of being a positive lymph nodes and the probability of being a negative lymph nodes when one lymph node is retrieved. The value of LODDS staging system on prognostic assessment for gastric cancer patients with R0 resection is still unclear.
METHODS:Clinicopathologic and prognostic data of...
BACKGROUND:Although surveillance for Barrett esophagus and other gastrointestinal precancerous conditions is recommended, no analogous guidelines exist for gastric lesions. The objective of this study was to estimate the clinical benefits and cost‐effectiveness of treatment and endoscopic surveillance to prevent gastric cancer.
METHODS:The authors developed a state‐transition decision model for a...
BACKGROUND:The purpose of this study was to compare 2 weekly docetaxel‐based regimens as first‐line treatments for advanced gastric cancer and to investigate the expression of secreted protein acidic and rich in cysteine (SPARC) and its abilities to predict treatment‐related clinical outcomes.
METHODS:Patients were randomly selected to receive 3 weekly cycles of docetaxel (35 mg/m2 on days 1 and...
BACKGROUND:The seventh edition of the American Joint Committee on Cancer (AJCC) TNM classification for gastric cancer was published in 2010 and included major revisions. The aim of the current study was to evaluate the validity of the seventh edition TNM classification for gastric cancer based on an Asian population.
METHODS:A total of 2916 gastric cancer patients who underwent R0 surgical resection...
BACKGROUND:Insulin‐like growth factor (IGF)‐I receptor (IGF‐IR) signaling is required for tumorigenicity and tumor progression of gastrointestinal cancers. The authors previously reported the success of therapy for gastrointestinal cancers using adenoviruses that expressed dominant‐negative IGF‐IR (IGF‐IR/dn). In addition, it has been demonstrated that IGF‐IR signaling affects vascular endothelial...
Metastatic brain tumors represent 20% to 40% of all intracranial neoplasms and are found most frequently in association with lung cancer (50%) and breast cancer (12%). Although brain metastases occur in <4% of all tumors of the gastrointestinal (GI) tract, the incidence of GI brain metastasis is rising in part due to more effective systemic treatments and prolonged survival of patients with GI...
BACKGROUND:Several trials have been conducted to determine the feasibility of preoperative radiotherapy (RT) for gastric cancer. However, the absolute benefit from radiotherapy remains to be defined. In this study, the authors examined the use of preoperative RT (Pre‐RT) and postoperative RT (PORT) in patients with gastric cancer from the Surveillance, Epidemiology, and End Results (SEER) database...
BACKGROUND:Fibroblast growth factor receptor 4 (FGFR4) belongs to the tyrosine kinase receptor family. Little is known about the effect of FGFR4 on gastric cancer (GC). Therefore, the objective of the current study was to elucidate the role of FGFR4 in the tumorigenesis and progression of GC.
METHODS:FGFR4 and some common prognosis markers, including p53, neu, and proliferating cell nuclear antigen...
BACKGROUND:A study was undertaken to determine the survival benefit of postoperative chemoradiation therapy for elderly patients with resected gastric adenocarcinoma.
METHODS:The authors identified 1023 individuals aged 65 years and older (median = 76) who underwent gastrectomy for nonmetastatic stage IB‐IV gastric adenocarcinoma diagnosed between 2000 and 2002 in the linked Surveillance, Epidemiology,...
BACKGROUND:By using genome‐wide methylation screening, the authors identified ring finger protein 180 (RNF180) as preferentially methylated in cancer. This study was undertaken to clarify its structure and functional role in gastric cancer.
METHODS:The transcription start site and core functional promoter region of RNF180 were revealed by 5′ rapid amplification of cDNA ends and luciferase activity...
BACKGROUND:The role of Epstein‐Barr virus (EBV) infection in gastric carcinogenesis remains largely unknown. The authors studied the effects of zinc finger E‐box binding factor 1 (ZEB1) on latent‐lytic switch of EBV infection in gastric cancer and explored the importance of EBV in gastric carcinogenesis.
METHODS:Loss or gain of ZEB1 function was obtained by ZEB1 small‐interfering RNA (siRNA) knock‐down...
BACKGROUND:Doxorubicin (Adriamycin) is effective in gastric cancer treatment, but with severe dose‐dependent toxicities. A novel prodrug of doxorubicin (Ac‐Phe‐Lys‐PABC‐ADM) is designed to deliver free doxorubicin relying on cathepsin B and reduce side effects. The authors examined the antitumor effect and toxicities of Ac‐Phe‐Lys‐PABC‐ADM against gastric cancer peritoneal carcinomatosis.
METHODS:SGC‐7901...
BACKGROUND:Helicobacter pylori infection causes gastric mucosal inflammatory responses, resulting in up‐regulation of interleukin‐1β (IL‐1β) and overproduction of mutagenic nitric oxide (NO). The authors previously demonstrated that IL‐1β plays an important role in H. pylori‐induced E‐cadherin (E‐cad) methylation. Here, they extend the study to investigate the downstream effect of IL‐1β on H. pylori...
BACKGROUND:Endoscopy screening in high‐risk populations may reduce gastric cancer mortality by detecting cancer earlier. We evaluated the association between the interval between upper gastrointestinal endoscopies and the gastric cancer stage at diagnosis in patients from a region of high prevalence.
METHODS:The study cohort consisted of 2485 patients diagnosed with gastric adenocarcinoma. We evaluated...
BACKGROUND:Gastritis cystica profunda (GCP) is a relatively rare disorder characterized by hyperplastic and cystic down growth of gastric glands into the submucosa. In the current study, the authors attempted to clarify the clinical and pathologic features of GCP in patients with gastric cancer.
METHODS:The records of 10,728 patients with gastric cancer who underwent gastric cancer surgery were reviewed...
BACKGROUND:The aim of this study was to examine prospectively the utility of adding preoperative [18F]fluorodeoxyglucose positron emission tomography (FDG‐PET)/computed tomography (CT) to routine CT, endoscopic ultrasound (EUS), and laparoscopic staging of localized gastric cancer.
METHODS:Patients with locally advanced gastric/gastroesophageal cancer were screened for 2 institutional review board–approved...
BACKGROUND:Annexin A1 (AnxA1) has been well‐known as a glucocorticoid‐regulated anti‐inflammatory protein, and it is implicated in tumorigenesis in a tumor type–specific pattern. However, the role of AnxA1 in gastric cancer (GC) is indeterminate, and the underlying mechanism is not clear. The purpose of this study was to evaluate the prognostic significance and associated mechanism of AnxA1 in GC...
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