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BACKGROUND
To the authors' knowledge, optimal adjuvant approaches for resected duodenal adenocarcinoma are not well established. Given the significant risk of locoregional disease recurrence, there may be a subset of patients who demonstrate an improvement in overall survival (OS) from the addition of radiotherapy (chemoradiotherapy [CRT]) to an adjuvant chemotherapy regimen.
METHODS
Patients with...
BACKGROUND
For women undergoing breast conservation therapy (BCT), the added value of breast magnetic resonance imaging (MRI) at the time of initial diagnosis remains controversial. The current study was performed to determine long‐term outcomes after BCT for women with and without pretreatment breast MRI.
METHODS
Between 1992 and 2001, a total of 755 women with ductal carcinoma in situ or early‐stage...
BACKGROUND
Failure‐free survival (FFS) and overall survival (OS) rates were found to improve on Intergroup Rhabdomyosarcoma Study (IRS) IV (IRS‐IV) compared with IRS‐III for patients with subset 2 (IRS stage 1, group III nonorbit or stage 3, group I/II) low‐risk embryonal rhabdomyosarcoma with the addition of cyclophosphamide (total cumulative cyclophosphamide dose of 26.4 g/m2) to the combination...
BACKGROUND
Indications for postmastectomy radiotherapy (PMRT) in patients with T1 to T2, lymph node‐negative (N0) breast cancer with “high‐risk” features are controversial. The European Organization for Research and Treatment of Cancer (EORTC) 22922 and National Cancer Institute of Canada Clinical Trials Group MA20 trials reporting improved 10‐year disease‐free survival with lymph node irradiation...
BACKGROUND
To measure the clinical impact of pretreatment fludeoxyglucose positron emission tomography/computed tomography (PET/CT) on the staging and management of apparent limited stage indolent lymphoma being considered for curative radiation therapy.
METHODS
We conducted a prospective multicenter registry study that included 197 patients accrued between May 1, 2012, and December 31, 2015. Pre‐PET/CT...
BACKGROUND
Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is a paucity of robust data with which to guide management decisions. The authors used the National Cancer Data Base to better understand the presenting characteristics of these tumors and to compare outcomes by treatment modality.
METHODS
The National Cancer Data Base was queried for sinonasal malignancies...
BACKGROUND
Patients with resectable esophageal cancer (rEC) are managed with either concurrent chemoradiotherapy followed by surgery (CRSx) or concurrent chemoradiotherapy alone (cCR). To the authors' knowledge, there is insufficient evidence comparing the overall survival of patients treated with these 2 options.
METHODS
The National Cancer Data Base was queried for rEC cases diagnosed from 2003...
BACKGROUND
The current study was conducted to compare the overall survival (OS) of concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in elderly patients (those aged ≥80 years) with muscle‐invasive bladder cancer (MIBC).
METHODS
Patients aged ≥80 years with cT2‐4, N0‐3, M0 transitional cell MIBC who were treated with curative RT (60‐70 Gray) or CCRT were identified in the National...
BACKGROUND
Proton radiotherapy remains a limited resource despite its clear potential for reducing radiation doses to normal tissues and late effects in children in comparison with photon therapy. This study examined the impact of race and socioeconomic factors on the use of proton therapy in children with solid malignancies.
METHODS
This study evaluated 12,101 children (age ≤ 21 years) in the...
BACKGROUND
Concurrent‐adjuvant chemoradiotherapy (CRT) became a recommended treatment for locoregionally advanced nasopharyngeal carcinoma (NPC) with the first report of a significant survival benefit from the Intergroup 0099 study. However, data on late toxicities are lacking. Previous reports from the current NPC‐9901 trial have raised concerns about a failure to improve overall survival (OS) because...
BACKGROUND
Patients with head and neck cancer (HNC) experience involuntary weight loss that has a negative impact on physical function, morbidity, and survival. The objective of the current study was to evaluate the feasibility of an exercise and nutrition intervention during radiotherapy (RT) compared with after RT, and to examine preliminary effects on skeletal muscle mass.
METHODS
Patients with...
The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low‐grade glioma and in a subset of glioblastoma. These mutations co‐occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor protein 53 (TP53) and alpha thalassemia/mental retardation (ATRX) mutations, which together help to define a molecular signature that aids in the...
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