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BACKGROUND
Hepatitis C virus (HCV) infection causes hepatocellular carcinoma (HCC) and subtypes of non‐Hodgkin lymphoma (NHL). Associations with other cancers are not established. The authors systematically assessed associations between HCV infection and cancers in the US elderly population.
METHODS
This was a registry‐based case‐control study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare...
BACKGROUND
Despite controversy surrounding its benefit, the use of concomitant chemoradiotherapy (CCRT) in patients with oropharyngeal squamous cell carcinoma (OPSCC) who are aged > 70 years is increasing. However, to the authors' knowledge, few studies to date have compared the outcomes of different systemic treatments in this population.
METHODS
Records from 74 patients aged ≥ 70 years with...
Immune checkpoint inhibitors, including those targeting the programmed cell death 1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are revolutionizing cancer therapeutics. Both activity and toxicities largely stem from unleashing tumor‐ or host‐specific cytotoxic T cells. Many patients seen in routine clinical practice have not qualified for or have been seriously underrepresented...
BACKGROUND
Allogeneic hematopoietic cell transplantation (HCT) offers curative potential to a number of older patients with acute myeloid leukemia (AML) in their first complete remission. However, there are limited data in the literature concerning post‐HCT outcomes for older patients in their second complete remission (CR2).
METHODS
The purpose of the current study was to retrospectively investigate...
BACKGROUND
Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo‐HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined.
METHODS
We analyzed 88 MDS patients aged ≥ 60 years with allo‐HSCT after reduced intensity conditioning regimens...
BACKGROUND
Clinical trials have established surgical resection and adjuvant chemotherapy (ACT) as the standard management for stage III colon cancer; however, the extent to which these results apply to elderly patients in routine practice is unclear. This article describes the management and outcomes of elderly patients with stage III colon cancer.
METHODS
All cases of surgically resected colon...
BACKGROUND
The objectives of this study were to characterize patterns of care and to identify predictors for adjuvant therapy in elderly patients with glioblastoma in the modern era. METHODS. The National Cancer Data Base was queried for patients aged 70 years and older with glioblastoma diagnosed from January 1, 2004 through December 31, 2012. Multinomial logistic regression was used to identify...
BACKGROUND
Conservative management of aggressive prostate cancer in the elderly without definitive therapy has been associated with a 10‐year prostate cancer‐specific mortality of approximately 50%. The authors examined the prevalence of definitive therapy in elderly patients with intermediate‐risk or high‐risk disease.
METHODS
411,343 patients who were diagnosed from 2004 through 2012 with intermediate‐risk...
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