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BACKGROUND
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. This report describes the survival of children with ALL in the United States using the most comprehensive and up‐to‐date cancer registry data.
METHODS
Data from 37 state cancer registries that cover approximately 80% of the US population were used. Age‐standardized survival up to 5 years was estimated for children...
BACKGROUND
The current study was performed to examine associations between childhood cancer therapies, chronic health conditions, and symptoms of emotional distress in adult survivors of childhood cancer.
METHODS
Participants included 5021 adult survivors of childhood cancer (mean age, 32.0 years [standard deviation, 7.6 years] with a time since diagnosis of 23.2 years [standard deviation, 4.5...
BACKGROUND
The objective of this study was to describe perceptions and associated risk factors of the impact of cancer on functional outcomes, including social relationships, exercise, finances, and religion, among adult survivors of childhood cancer.
METHODS
Evaluable participants included 3001 adult survivors (mean age, 32.5 years; range, 18.3‐63.8 years; 24.1 years from diagnosis; 50.8% male;...
BACKGROUND
Risk factors for impairment in psychosexual development and satisfaction among adult survivors of childhood cancer are poorly understood. The authors compared psychosexual outcomes between survivors and healthy controls, and tested whether at‐risk survivors can be identified by 1) treatment neurotoxicity or 2) diagnosis.
METHODS
A total of 144 young adult survivors of childhood cancer...
BACKGROUND
The tumor protein p53 (TP53) arginine‐to‐histidine mutation at codon 337 (R337H) predisposes children to adrenocortical tumors (ACTs) and, rarely, to other childhood tumors, but its impact on adult cancer remains undetermined. The objective of this study was to investigate the frequency and types of cancer in relatives of children with ACT who carry the TP53 R337H mutation.
METHODS
TP53...
BACKGROUND
The medical traumatic stress model is commonly applied to childhood cancer, assuming that the diagnosis of cancer is a traumatic event. However, to the authors' knowledge, little is known regarding what specifically children perceive as stressful about cancer or how it compares with other stressful events more often experienced by children.
METHODS
Children with cancer (254 children)...
BACKGROUND
Cancer survivors transfused with blood products before reliable screening for hepatitis C virus (HCV) are at risk for infection. This study examined the impact of HCV on neurocognitive function and health‐related quality of life (HRQOL) among adult survivors of childhood cancer.
METHODS
Neurocognitive testing was conducted for 836 adult survivors of childhood cancer (mean age, 35 years...
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