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BACKGROUND
Intensity‐modulated radiation therapy (IMRT) is a technologically advanced and resource‐intensive method of delivering radiation therapy (RT) and is used to minimize toxicity for patients with head and neck cancer (HNC). Dependence on feeding tubes is a significant marker of toxicity of RT. The objective of this analysis was to compare the placement and duration of feeding tube use among...
BACKGROUND
Given the rarity of anal cancer and the technical aspects involved in radiation (RT) planning, the authors conducted a population‐based analysis evaluating the impact of radiation oncology facility volume on overall survival (OS) in patients with squamous cell carcinoma (SCC) of the anal canal.
METHODS
The National Cancer Data Base (NCDB) was queried for patients with SCC of the anal...
BACKGROUND
The Patient‐Reported Outcomes Measurement Information System (PROMIS) was a National Institutes of Health‐funded initiative to develop measures of symptoms and function. Responsiveness is the degree to which a measure can detect underlying changes over time. The objective of the current study was to document the responsiveness of 8 PROMIS measures in a large, population‐based cancer cohort...
BACKGROUND
Mammographic calcifications can be a marker of malignancy, but their association with prognosis is less well established. In the current study, the authors examined the relationship between calcifications and breast cancer prognostic factors in the population‐based Carolina Mammography Registry.
METHODS
The current study included 8472 invasive breast cancers diagnosed in the Carolina...
The treatment of advanced renal cell carcinoma has posed a challenge for decades, in part because of common themes related to intrinsic resistance to cytotoxic chemotherapy and the obscure biology of these cancer types. Forward movement in the treatment of the renal cell carcinomas thus can be approached in 2 ways: by splitting the tumor types along histologic and molecular features, in the hopes...
BACKGROUND
This randomized, double‐blind, phase 2 trial evaluated whether the addition of vandetanib to platinum plus etoposide for previously untreated extensive‐stage small cell lung cancer (SCLC) prolonged the time to disease progression in comparison with chemotherapy alone.
METHODS
Patients with previously untreated extensive‐stage SCLC received platinum (cisplatin or carboplatin) with etoposide...
BACKGROUND
Improving care coordination is a key priority for health services. The aims of this study were to identify patient‐ and health service–related predictors of poorly coordinated care and to explore patient preferences to assist care coordination.
METHODS
Patients with incident colorectal cancer, identified from a state‐wide cancer registry, completed a self‐report questionnaire 6 to 8...
BACKGROUND
Providing high‐quality medical care for individuals with cancer during their last year of life involves a range of challenges. An important component of high‐quality care during this critical period is ensuring optimal patient satisfaction. The objective of the current study was to assess factors influencing health care ratings among individuals with cancer within 1 year before death....
BACKGROUND
Increased susceptibility to 5‐fluorouracil (5‐FU)/capecitabine can lead to rapidly occurring toxicity caused by impaired clearance, dihydropyrimidine dehydrogenase deficiency, and other genetic variations in the enzymes that metabolize 5‐FU. Life‐threatening 5‐FU overdoses occur because of infusion pump errors, dosage miscalculations, and accidental or suicidal ingestion of capecitabine...
BACKGROUND
Many men with prostate cancer (PC) require long‐term androgen deprivation therapy (ADT), but to the authors' knowledge, its effects on cognitive function beyond 1 year are not described.
METHODS
Three groups of men aged ≥50 years who were matched based on age and education were enrolled: 77 patients with nonmetastatic PC who initiated continuous ADT, 82 patients with PC who were not...
BACKGROUND
Whether patient navigation improves outcomes for patients with comorbidities is unknown. The aims of this study were to determine the effect of comorbidities on the time to diagnostic resolution after an abnormal cancer screening test and to examine whether patient navigation improves the timeliness and likelihood of diagnostic resolution for patients with comorbidities in comparison with...
BACKGROUND
Minimal residual disease (MRD) assessment predicts survival for patients with newly diagnosed acute lymphoblastic leukemia (ALL). Its significance in relapsed/refractory ALL is less clear.
METHODS
This study identified 78 patients with relapsed/refractory B‐cell ALL who achieved a morphologic response with inotuzumab ozogamicin (n = 41), blinatumomab (n = 11), or mini‐hyperfractionated...
BACKGROUND
Patients with metastatic castration‐resistant prostate cancer (mCRPC) and visceral metastases have a worse prognosis than those with nonvisceral metastases. Treatment with the androgen receptor inhibitor enzalutamide in the phase 3 AFFIRM trial led to significant improvements in outcomes for patients with mCRPC. For the current report, the authors analyzed the efficacy of enzalutamide...
BACKGROUND
Previously proposed criteria for preoperatively identifying endometrial cancer patients at low risk for lymph node metastasis remain to be verified. For this purpose, a prospective, multicenter observational study was performed.
METHODS
Eligible patients with histologically confirmed endometrial cancer underwent magnetic resonance imaging (MRI) and serum cancer antigen 125 (CA 125) testing...
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