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BACKGROUND:In this study, the authors evaluated the effect of denosumab versus zoledronic acid (ZA) on pain in patients with advanced breast cancer and bone metastases.
METHODS:The prevention of pain, reduction in pain interference with daily life activities, and the proportion of patients requiring strong opioid analgesics were assessed in a randomized, double‐blind, double‐dummy phase 3 study comparing...
BACKGROUND:Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women with breast cancer susceptibility gene (BRCA) mutations. Unspecified details of screening schedules are a challenge for implementing guidelines.
METHODS:A Markov Monte Carlo computer model was used to simulate screening in asymptomatic...
BACKGROUNDRates of nonadherence to aromatase inhibitors (AIs) among Medicare beneficiaries with hormone receptor‐positive early breast cancer are high. Out‐of‐pocket drug costs appear to be an important contributor to this and may be addressed by eliminating copayments and other forms of patient cost sharing. The authors estimated the incremental cost‐effectiveness of providing Medicare beneficiaries...
BACKGROUNDMore than 80,000 postmenopausal breast cancer patients in the United States each year are estimated to begin a 5‐year course of aromatase inhibitors (AIs) to prevent recurrence. AI‐related arthralgia (joint pain and/or stiffness) may contribute to nonadherence, but longitudinal data are needed on arthralgia risk factors, trajectories, and background in postmenopause. This study sought to...
BACKGROUNDAndrogen receptor (AR) expression in breast cancers may serve as a prognostic and predictive marker. We examined the expression pattern of AR and its phosphorylated forms, Ser‐213 (AR‐Ser[P]‐213) and Ser‐650 (AR‐Ser[P]‐650), in breast cancer and evaluated their association with clinicopathological parameters.
METHODSImmunohistochemistry was performed on primary and distant metastatic breast...
BACKGROUNDPrimary care physician (PCP) services may have an impact on breast cancer mortality and incidence, possibly through greater use of screening mammography.
METHODSThe authors conducted a retrospective, 1:1 matching case‐control study using the Surveillance, Epidemiology, and End Results (SEER)‐Medicare–linked database to examine use of PCP services and their association with breast cancer...
BACKGROUNDSome false‐positive results are inevitable in mammographic screening, but the impact of false‐positive findings on the program and the participants is a disadvantage of screening. The objective of the current study was to estimate the cumulative risk of a false‐positive result over 10 biennial screening examinations and the cumulative risk of undergoing an invasive procedure with a benign...
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