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BACKGROUNDSignet ring cell esophageal adenocarcinoma histology has been difficult to study in single institution series because of its relative rarity, yet has an anecdotal reputation for poor prognosis. The Surveillance, Epidemiology, and End Results (SEER) database was examined to assess the prognostic implications of this esophageal adenocarcinoma subtype.
METHODSAll patients with esophageal adenocarcinoma...
BACKGROUNDBoth everolimus and temozolomide are associated with single‐agent activity in patients with pancreatic neuroendocrine tumor (NET). A phase 1/2 study was performed to evaluate the safety and efficacy of temozolomide in combination with everolimus in patients who have advanced pancreatic NET.
METHODSPatients were treated with temozolomide at a dose of 150 mg/m2 per day on days 1 through 7...
BACKGROUNDIndividuals with a history of colorectal cancer (CRC) have an increased risk of subsequent cancer. In this study, the authors used cancer registry data to evaluate whether this increased risk of cancer after CRC differed by anatomic subsite of a first CRC.
METHODSIndividuals diagnosed with a first primary CRC between 1992 and 2009 were identified from 12 Surveillance, Epidemiology, and...
BACKGROUNDBecause anaplastic thyroid cancer is a rare malignancy with a high mortality rate, the benefit of multimodality treatment was evaluated.
METHODSOverall survival was determined in the 2742 patients captured by the National Cancer Database who were diagnosed with anaplastic thyroid cancer between 1998 and 2008. Kaplan‐Meier analysis and then Cox proportional hazard regression was performed,...
BACKGROUNDPatients diagnosed with prostate cancer are often counseled about treatment options with the use of terms that are part of the “core vocabulary” of prostate cancer. It is hypothesized that predominantly lower literacy patients would demonstrate a severe lack of comprehension of prostate cancer terms, thus validating the findings of a previous single‐institution study.
METHODSA previously...
BACKGROUNDExcision repair cross‐complementing gene‐1 (ERCC1) and thymidylate synthase (TS) are key regulatory enzymes whose expression patterns are associated with overall survival (OS) in several malignancies. Their expression patterns and prognostic value in resected gastric adenocarcinoma (GAC) are not known.
METHODSIn total, 109 patients who underwent resection for GAC between January 2000 and...
BACKGROUNDThe Norwegian Breast Cancer Screening Program started in 1996. To the authors' knowledge, this is the first report using individual‐based data on invitation and participation to analyze breast cancer mortality among screened and nonscreened women in the program.
METHODSInformation on dates of invitation, attendance, breast cancer diagnosis, emigration, death, and cause of death was linked...
BACKGROUNDFluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost‐effectiveness of expanded retesting to assess HER2 tumor status in women with early stage breast cancer.
METHODSWe developed a decision‐analytic model to...
BACKGROUNDThis study sought to compare the clinical outcomes of upper versus whole‐neck prophylactic irradiation in the treatment of patients with node‐negative nasopharyngeal carcinoma (NPC).
METHODSBetween November 2005 and June 2012, 301 patients with node‐negative NPC were randomly assigned to receive primary plus prophylactic upper neck irradiation (UNI, 153 patients) or primary plus whole‐neck...
BACKGROUNDSleep disturbance is a common clinical complaint of oncology patients and contributes to substantial morbidity. However, because most sleep studies have been cross‐sectional, associations between sleep quality and distress in patients with ovarian cancer over time remain unclear. This prospective longitudinal study examined rates of sleep disturbance; contributions of depression, anxiety,...
BACKGROUNDParatesticular rhabdomyosarcoma (PTRMS) is the most common primary solid tumor arising from the mesenchymal tissue of the testis. Traditionally, retroperitoneal lymph node dissection is not recommended for children aged <10 years because of the morbidity of the procedure and low risk of retroperitoneal lymph node involvement. In the current study, the authors analyzed the patient and...
BACKGROUNDPatients with bladder cancer are apt to develop multiple recurrences that require intervention. The recurrence, progression, and bladder cancer–related mortality rates were examined in a cohort of individuals with high‐grade non–muscle‐invasive bladder cancer.
METHODSUsing linked Surveillance, Epidemiology, and End Results (SEER)‐Medicare data, subjects were identified who had a diagnosis...
BACKGROUNDLittle is known regarding racial disparities in characteristics and outcomes among patients with chronic lymphocytic leukemia (CLL).
METHODSThe characteristics and outcomes of untreated African American (AA) patients with CLL (n = 84) were analyzed and compared with a reference nonblack (NB) patient population (n = 1571).
RESULTSAt the time of presentation, AA patients had lower median...
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