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BACKGROUND:The authors sought to determine the incidence and severity of cardiovascular toxicity caused by imatinib mesylate in gastrointestinal stromal tumor (GIST) and other sarcoma patients, and to explore cardiotoxicity caused by imatinib mesylate using cell culture and in vitro models.
METHODS:To determine the incidence and significance of serious cardiac adverse events in GIST and other sarcoma...
BACKGROUND:This study was conducted to develop a histology‐specific nomogram to predict postoperative overall survival (OS) at 5 and 10 years in primary retroperitoneal soft tissue sarcoma (STS).
METHODS:Data registered at a single institution (National Cancer Institute, Milan, Italy) prospective sarcoma database were used. In the present analysis, patients with primary localized retroperitoneal...
BACKGROUND:The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This is a report of long‐term (≥5 years) follow‐up in patients with high‐grade, high‐risk soft tissue sarcomas treated with neoadjuvant chemotherapy, preoperative radiotherapy (RT), and adjuvant chemotherapy.
METHODS:Patients with high‐grade soft tissue sarcoma ≥8 cm in diameter of the extremities...
BACKGROUND:Acral myxoinflammatory fibroblastic sarcoma (AMFS) is a rare, low‐grade sarcoma that commonly affects the distal extremities. From the published cases, therapy for AMFS to date has been comprised of excision or amputation, with limited use of radiotherapy (RT) or chemotherapy. In this report, the outcome of 17 patients with AMFS treated at the study institution was reported.
METHODS:A...
BACKGROUND:The objective of this study was to assess patient, tumor, and treatment factors that affected overall survival in a group of patients who underwent surgery for soft tissue sarcoma (STS) and presented with American Joint Commission on Cancer stage IV disease.
METHODS:A retrospective review was undertaken of a single institution's database from the years 1986 to 2006 in all patients who...
BACKGROUND:The objective of this study was to determine whether the overall survival of patients with metastatic soft tissue sarcoma (STS) has improved over the last 20 years.
METHODS:In total, 1024 patients who had synchronous metastatic (SM) STS or metachronous metastatic (MM) STS diagnosed between 1987 and 2006 were included prospectively in the French Sarcoma Group database after central histologic...
BACKGROUND:Although a rare complication of ionizing radiation, radiation‐induced osteosarcoma is now more frequently recognized as radiation therapy has become common and cancer survival has increased. To date, publications on radiation‐induced osteosarcoma of the cranium are limited to a few small series and case reports.
METHODS:Data from 175 patients with a history of sarcoma of the head at The...
BACKGROUND:Soft tissue sarcomas (STSs) arising from the popliteal fossa present a challenge with regard to local control of primary tumors. Due to concerns of functional morbidity and neurovascular compromise, there is debate about what represents the best therapy for these patients.
METHODS:We conducted a retrospective medical record review of patients treated at The University of Texas M. D. Anderson...
BACKGROUND:Based on results of a prospective randomized trial, brachytherapy (BRT) had been the preferred form of adjuvant radiotherapy for patients with high‐grade extremity soft tissue sarcoma (STS) at our institution. In recent years, intensity‐modulated radiotherapy IMRT had been increasingly used. This study compared local control by IMRT versus by BRT in primary‐extremity STS.
METHODS:Between...
BACKGROUND:Rhabdomyosarcoma (RMS), the most common soft‐tissue sarcoma in children, occurs less commonly in infants. Historically, poorer outcomes have been reported for infants diagnosed with RMS than for older children.
METHODS:The authors analyzed the characteristics, treatment administered, outcomes, and patterns of failure for infants aged < 1 year with nonmetastatic RMS who received multimodal...
BACKGROUND:The objective of this study was to determine whether specific single nucleotide polymorphisms (SNPs) from nucleotide excision repair (NER) and homologous recombination (HR) DNA repair pathways are associated with sensitivity to trabectedin in patients with soft tissue sarcoma (STS).
METHODS:The authors analyzed excision repair cross‐complementation group 5/xeroderma pigmentosum group G...
BACKGROUND:Many elderly patients with cancer experience increased cancer‐related morbidity and mortality compared with younger patients. In soft tissue sarcoma, adjuvant radiotherapy is an integral part of definitive therapy for limb preservation. The authors of this report hypothesized that age‐related disparities exist in the use of radiation.
METHODS:Surveillance, Epidemiology, and End Results...
The authors undertook a systematic review to designate the role that radiotherapy (RT) might play in the treatment of retroperitoneal sarcomas. Correlating with recent literature, the objective of this review was to evaluate whether there was enough evidence for the authors to develop an institutional treatment protocol concerning the use of RT in the treatment of retroperitoneal sarcoma. Furthermore,...
BACKGROUND:A study was undertaken to assess clinical outcome and the role of proton therapy for local control of osteosarcoma (OSA).
METHODS:All patients who received proton therapy or mixed photon‐proton radiotherapy from 1983 to 2009 at the Massachusetts General Hospital were reviewed. Criteria for proton therapy were the need for high dose in the context of highly conformal radiotherapy of unresected...
BACKGROUND:Cancer survivors are at increased risk for second malignancies, and vigilance is thus required. The authors sought to determine whether there was an association among lymphoma, sarcoma, and the associated treatments for these diseases.
METHODS:From the authors' prospective soft tissue sarcoma (STS) database of 8240 patients, they identified 112 patients with STS and lymphoma treated from...
BACKGROUND:Human tumors transplanted into immunodeficient mice (xenografts) are good preclinical models, and it is important to identify possible systematic changes during establishment and passaging in mice.
METHODS:High‐resolution microarray‐based comparative genomic hybridization (array CGH) was used to investigate how well a series of sarcoma xenografts, including 9 patient/xenograft pairs and...
BACKGROUND:Sarcoma is the index diagnosis of Li‐Fraumeni syndrome (LFS), a familial predisposition to cancer that also includes brain cancer, breast cancer, and adrenal cortical carcinoma. Germline mutations in the TP53 gene are detected in approximately 80% of families that fulfill LFS criteria and in 15% to 25% of families that fulfill criteria for Li‐Fraumeni‐like syndrome (LFS), a group of related...
Although sarcomas account for a small portion of solid malignancies, currently, there are few treatment options for sarcomas, particularly for advanced disease. The mammalian target of rapamycin (mTOR), a serine‐threonine protein kinase in the phosphatidylinositol 3‐kinase/serine/threonine protein kinase Akt signaling pathway, has an important role in the regulation of protein synthesis, cell proliferation,...
BACKGROUND:Sarcoma metastases to the skin are relatively rare, because most involve the lung, liver, or deep soft tissues. The authors of this report examined the distribution and clinical significance of cutaneous and superficial subcutaneous sarcoma metastases.
METHODS:Sixty‐five patients with histologically confirmed dermal and superficial subcutaneous sarcoma metastases were identified in pathology...
BACKGROUND:This study sought to determine whether [18F]fluorothymidine (FLT) positron emission tomography (PET)/computed tomography (CT) imaging allows assessment of tumor viability and proliferation in patients with soft tissue sarcomas who are treated with neoadjuvant therapy.
METHODS:Twenty patients with biopsy‐proven, resectable, high‐grade soft tissue sarcoma underwent [18F]FLT PET/CT imaging...
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