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BACKGROUNDUS breast cancer deaths have been declining since 1989, but African American women are still more likely than white women to die of breast cancer. Black/white disparities in breast cancer mortality rate ratios have actually been increasing.
METHODSAcross 762 US counties with enough deaths to generate reliable rates, county‐level, age‐adjusted breast cancer mortality rates were examined...
BACKGROUNDRadiotherapy (RT), short‐course androgen deprivation therapy (ADT), and brachytherapy in various combinations are treatment options for patients with intermediate‐risk prostate cancer (PC), but the question of which combination if any is necessary to minimize PC‐specific mortality (PCSM) risk in patients with favorable or unfavorable intermediate‐risk PC is unknown. The authors assessed...
Mu opioids are among the most widely used drugs for patients with cancer with both acute and chronic pain as well as in the perioperative period. Several retrospective studies have suggested that opioid use might promote tumor progression and as a result negatively impact survival in patients with advanced cancer; however, in the absence of appropriate prospective validation, any changes in recommendations...
BACKGROUNDHealth care utilization in older adults (age ≥60 years) with acute myeloid leukemia (AML) has not been well studied.
METHODSWe conducted a retrospective analysis of 330 consecutive older patients who were diagnosed with AML between May 1, 2005 and December 23, 2011, at 2 hospitals in Boston to examine their health care utilization and end‐of‐life care. Using multivariable logistic and linear...
BACKGROUNDPatients with colorectal cancer (CRC) who undergo cancer surgeries with higher‐volume providers may have better outcomes. The current debate focuses on whether it is hospital volume or surgeon volume that matters more.
METHODSThe authors conducted a nationwide population‐based study in Taiwan that enrolled all patients who underwent definitive surgery for newly diagnosed CRC between 2005...
BACKGROUNDCervical intraepithelial neoplasia grade 2, 3, and adenocarcinoma in situ (CIN2+) lesions can be monitored as early indicators of human papillomavirus (HPV) vaccine impact. Changes to screening utilization will affect observed reductions in CIN2+ rates and complicate the interpretation of vaccine impact.
METHODSFrom 2008 to 2012, 9119 cases of CIN2+ among 18‐ to 39‐year‐old residents of...
BACKGROUNDThe current study examined effects, moderators (for whom), and mediators (working mechanisms) of 12 months of exercise on health‐related quality of life (HRQoL) in older long‐term survivors of prostate cancer.
METHODSIn total, 100 men aged 71.7 years (standard deviation, 6.4 years) were randomly assigned to 6 months of supervised aerobic and resistance exercise followed by 6 months of a...
BACKGROUNDRandomized trials have shown that intermittent treatment may reduce toxicity without compromising survival in patients with metastatic colorectal cancer (mCRC). A population‐based study examined patterns of use of chemotherapy‐free intervals (CFIs) in routine practice in Ontario and their impact on survival and toxicity.
METHODSPatients treated with first‐line intravenous chemotherapy for...
BACKGROUNDBreast cancer survivors on aromatase inhibitors often experience joint pain as a side effect of their treatment; qualitative investigations suggest that this arthralgia may cause women to feel that they are aging faster than they should be. To facilitate further study of this experience, the Penn Arthralgia Aging Scale (PAAS) was developed. This report describes the development and validation...
BACKGROUNDSingle nucleotide polymorphism (SNP) of the excision repair cross‐complementing group 1 (ERCC1) gene has been linked with sensitivity to platinum and radiation. The authors hypothesized that the ERCC1 genotype for the SNPs cytosine‐to‐thymine substitution at codon 118 (C118T) and cytosine‐to‐adenine substitution at codon 8092 (C8092A) is prognostic in patients with nasopharyngeal carcinoma...
BACKGROUNDThe purpose of the current study was to examine the effect of an oncologist's exercise recommendation with and without an exercise motivation package on the amount of exercise participation and quality of life (QOL) in survivors of breast and colorectal cancer.
METHODSA total of 162 survivors of early‐stage breast and colorectal cancer who completed primary and adjuvant treatments were...
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