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BACKGROUNDTargeting the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is of increasing interest as a therapeutic strategy in many tumors. The aim of this study was to identify molecular markers associated with mTOR inhibitor activity in women with metastatic endometrial cancer.
METHODSArchival tumor samples were collected from 94 women with recurrent or metastatic...
BACKGROUNDMetformin, an antidiabetic drug, decreases the incidence of various cancers in diabetic patients. Metformin‐induced inhibition of cancer cell proliferation has been confirmed in vitro but not in humans. Because endometrial cancer is associated with insulin resistance, the authors investigated whether a diabetes‐therapeutic metformin dose inhibits cancer cell growth in patients with endometrial...
BACKGROUNDLiver kinase B1 (LKB1) is a serine/threonine kinase that functions as a tumor suppressor and regulates cell polarity, proliferation, and metabolism. Mutations in LKB1 are associated with Peutz‐Jeghers syndrome as well as sporadic cervical and lung cancers. Although LKB1‐null mice develop invasive endometrial cancers, the role and regulation of LKB1 in the pathogenesis of human endometrial...
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