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Melanoma is one of the most highly mutated malignancies, largely as a function of its generation through ultraviolet light and other mutational processes. The wide array of mutations in both “driver” and “passenger” genes can present a confusing array of data for practitioners, particularly within the context of the recent revolutions in targeted and immune therapy. Although mutations in BRAF V600...
BACKGROUND
Partial prostate treatment has emerged as a potential method for treating patients with favorable‐risk prostate cancer while minimizing toxicity. The authors previously demonstrated poor rates of biochemical disease control for patients with National Comprehensive Cancer Network (NCCN) intermediate‐risk disease using partial gland treatment with brachytherapy. The objective of the current...
Hepatocellular carcinoma (HCC) is increasing in incidence and mortality. Although the prognosis remains poor, long‐term survival has improved from 3% in 1970 to an 18% 5‐year survival rate today. This is likely because of the introduction of well tolerated, oral antiviral therapies for hepatitis C. Curative options for patients with HCC are often limited by underlying liver dysfunction/cirrhosis and...
BACKGROUND
This study was designed to identify preoperative predictors of survival in surgically treated patients with metastatic epidural spinal cord compression (MESCC), to examine how these predictors are related to 8 prognostic models, and to perform the first full external validation of these models in accordance with the Transparent Reporting of a Multivariable Prediction Model for Individual...
BACKGROUND
The incidence of rectal cancer in patients younger than 50 years is increasing. To test the hypothesis that the biology in this younger cohort may differ, this study compared survival patterns, stratifying patients according to National Comprehensive Cancer Network (NCCN) guideline–driven care and age.
METHODS
The National Cancer Data Base was queried for patients treated with curative‐intent...
BACKGROUND
The objective of this study was to investigate the prevalence of pathogenic germline variants (PGVs) in 32 cancer susceptibility genes in individuals with newly diagnosed pancreatic ductal adenocarcinoma (PDAC). A key secondary objective was to evaluate how often PGVs would have been undetected with existing genetic testing criteria.
METHODS
From May 2016 through May 2017, this multicenter...
BACKGROUND
Assessing trends in breast cancer survival among young women who are largely unaffected by breast cancer screening will provide important information regarding improvements in the effectiveness of cancer care for breast cancer in the last few decades.
METHODS
The cohort for this study consisted of women who were diagnosed with breast cancer between ages 20 and 39 years from the Surveillance,...
BACKGROUND
Threatening illness perceptions (IPs) have been associated with poorer health outcomes. However, to the authors' knowledge, it remains unclear whether threatening IPs that are consistent with disease severity are equally harmful. The aim of the current study was to: 1) identify subgroups of cancer survivors based on IPs and prognosis; and 2) assess the health‐related quality of life (HRQOL)...
BACKGROUND
The incidence of hepatocellular carcinoma (HCC) has been rising rapidly in the United States. California is an ethnically diverse state with the largest number of incident HCC cases in the country. Characterizing HCC disparities in California may inform priorities for HCC prevention.
METHODS
By using data from the Surveillance, Epidemiology, and End Results 18‐Registry Database and the...
BACKGROUND
Although survivors of adolescent‐onset cancers are at risk of infertility, the majority desire children. Fertility preservation options are available for adolescents, but sperm banking remains underused. To the authors' knowledge, patient factors that influence decisions to bank sperm are poorly understood.
METHODS
A cross‐sectional study of 146 adolescent males who were newly diagnosed...
BACKGROUND
Glucocorticoids can lead to weight gain during cancer treatment, but to the authors' knowledge, little is known regarding their long‐term effects in childhood cancer survivors (CCS).
METHODS
As part of the Swiss Childhood Cancer Survivor Study, the authors sent a questionnaire to CCS aged <21 years at diagnosis who were residing in Switzerland, had survived ≥5 years, and were aged...
BACKGROUND
The purpose of this study was to examine the prevalence and predictors of social difficulties in adolescent survivors of central nervous system (CNS) tumors.
METHODS
Six hundred sixty‐five survivors of CNS tumors (53.8% male and 51.7% treated with cranial radiation therapy [CRT]), who had a current median age of 15.0 years (range, 2.0‐17.0 years) and were a median of 12.1 years (range,...
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