Objective
To evaluate the effects of a toothpaste containing 0.3% triclosan in volunteers that have been treated for peri‐implantitis and were enrolled in a maintenance program.
Material and methods
Subjects presenting at least one implant with peri‐implantitis were selected. They received anti‐infective surgical therapy, and sixty days post‐surgery (baseline) were randomized into two groups, brushing twice/day for 2 years (a) with a toothpaste containing 0.3% triclosan+2.0% PVM/MA copolymer (GantrezTM)+1,450 ppm fluoride (test) or (b) with a toothpaste containing 1,450 ppm fluoride (control). They received clinical and microbiological monitoring at baseline, 3, 6, 12, 18, and 24 months, and professional maintenance every 3 months.
Results
A total of 102 subjects were enrolled (test: 48; control: 54). The control group showed loss of clinical attachment (CA) around treated implants over the course of the study (p < 0.05), while the test group was stable for this parameter. The difference between groups (0.55 mm) for CA change between baseline and 24 months (primary outcome variable) was statistically significant (p < 0.05). Red complex pathogens were only reduced in the test group at 24 months. The implants with no history of peri‐implantitis in the test group had a significant reduction in the percentage of sites with bleeding on probing and in mean probing depth, throughout the study (p < 0.05). This improvement was not observed in the control group.
Conclusion
A toothpaste containing 0.3% triclosan was more effective than a toothpaste without triclosan in maintaining a healthy peri‐implant environment around treated implants and implants with no history of peri‐implantitis during a 2‐year maintenance program (ClinicalTrials.govNCT03191721).