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The cover picture shows the construction of novel supramolecular prodrug micelles based on the host‐guest interaction of water‐soluble pillar[6]arene (WP6) and doxorubicin (DOX)‐based drug‐drug conjugate (G). Herein, the release rate of DOX from these supramolecular micelles is approximate to 100% within 30 min at pH 5.5 by simulating the endo‐lysosomal environment. Significantly, intracellular localization...
The first attempt of constructing supramolecular prodrug micelles based on the host‐guest interaction between water‐soluble pillar[6]arene (WP6) and a novel doxorubicin (DOX)‐based drug‐drug conjugate (G) is reported, in which the drug‐drug conjugate is synthesized by conjugating anticancer drug DOX with another drug isoniazide via the acid‐cleavable hydrazone bond. The obtained WP6⊃G micelles are...
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