There is abundant literature demonstrating that entrepreneurial orientation has an impact on performance indicators including economic results and relative market share. Moreover, entrepreneurial orientation interacts with market orientation to improve performance. Human resources information management (HRIM) is a critical component of market orientation. We tested a structural model of relationships among entrepreneurial orientation (EO), HRIM, and firm performance using a sample of small and medium sized enterprises (SMEs) from the manufacturing sector of Portugal. EO had a positive direct effect on both performance (β = .313) and HRIM (β = .291). HRIM also had a positive effect on firm performance (β = .236), and EO indirectly impacted firm performance (.069) through HRIM. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.