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The BaySHAKE® single‐use bioreactor is based on the motion principle of rotary oscillation of a polyhedral container. This fundamental working principle facilitates mixing and oxygen transfer to animal cell cultures in a simple, robust and cost‐efficient single‐use system without internal moving parts. In‐depth hydrodynamic characterization shows that the bioreactor provides mixing and oxygen transfer...
A systematic and integrated use of single‐use technologies was combined with a robust monoclonal antibody platform, which led to a substantial reduction of manufacturing costs, reduced timelines and increased flexibility in clinical manufacturing. A direct scale‐up of a high titer monoclonal antibody‐expressing CHO DG44‐based cell culture platform was performed from shake flasks to a 1000 L production...
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