Droplet separators, or mist eliminators, are a very important internal part of fluid separation columns. They remove liquid droplets or mist from the gas stream and are installed at the top of the column with vertical gas or vapor flow. They reduce emissions to the atmosphere or to subsequent process steps. Droplet separators even can increase the separation efficiency of fluid separation processes, like absorption, desorption, distillation, evaporation etc. In this work the approach to develop a new vane type droplet separator for separation columns based on experimental investigation and CFD analysis is presented. The new droplet separator has a higher separation efficiency at the same pressure drop compared to state‐of‐the‐art standard droplet separators.