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Magnetic circular dichroism (MCD) spectroscopy is a powerful method for evaluating the electronic structure and magnetic and optical properties of molecules. In particular, MCD measurements have been performed on phthalocyanines and porphyrins with various central metal ions, axial ligands, and substituents to elucidate their properties. It is essential to develop a robust high‐throughput technique...
The emergence of new synthetic cathinones continues to be a matter of public health concern. In fact, already known products (drugs) are being rapidly replaced by new structurally related alternatives, whereby modifications in the basic cathinone structure are used by manufacturers to circumvent the legislation. On the other hand, some derivatives of synthetic cathinones represent important pharmaceuticals...
A novel bis‐triazolyl bridged β‐cyclodextrin was first synthesized by the Click reaction between azido‐β‐cyclodextrin and 1,6‐heptadiyne. Then it was bonded onto silica gel to obtain a bis‐triazolyl bridged β‐cyclodextrin‐based chiral stationary phase (BCDP). After structure characterization, the HPLC performance of BCDP was systematically evaluated by using different types of compounds as probes...
We are looking into how well a copolymeric material made of poly (maleic acid–co‐4‐vinylpyridine) cross‐linked with divinylbenzene can separate L‐norepinephrine (L‐NEP) from (±)‐NEP. The initial step in this direction was the synthesis and subsequent analysis of L‐NEP‐maleimide chiral derivative. A 4‐vinylpyridine/divinylbenzene combination was copolymerized with the resultant chiral maleimide. After...
Ibuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti‐inflammatory drug (NSAID) comprising two enantiomers, (R)‐IBP and (S)‐IBP, collectively known as (RS)‐IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The...
(S)‐Lifitegrast (LFT) is the novel integrin antagonist, approved by the Food and drug administration, to treat signs and symptoms of dry eye disease. Synthesis of racemic LFT, preparative and analytical enantiomer separation, and chiral interconversion studies are lacking in the literature. Hence, in our study, synthesis of LFT racemate, chiral preparative purification procedure of enantiomer, and...
To investigate the thermodynamic and molecular self‐assembly mechanism of trans‐1,2‐cyclohexane dicarboxylic acid containing two carboxylic acid groups in the chiral resolution process, (S)‐phenylethylamine was used as the chiral resolving agent. Two stoichiometric salts were formed when the raw materials were fed at different molar ratios: cyclohexane dicarboxylate monophenylethylamine salt and cyclohexane...
To quantify chiral shape, a tensor describing the particle shape has been proposed. This tensor, named the shape tensor (S‐tensor), is an analog of the hydrodynamic tensor that relates the rotational and translational motions of particles in a liquid. The determinant of the S‐tensor, named chirality measure density (CMD), was calculated for chiral tetrahedrons and octahedrons. It was found that CMD...
Helicenes represent an important class of chiral organic material with promising optoelectronic properties. Hence, functionalization of surfaces with helicenes is a key step toward new organic materials devices. The deposition of a heterohelicene containing two furano groups and two hydroxyl groups onto copper(111) surface in ultrahigh vacuum leads to different adsorbate modifications. At low coverage...
Chiroptical properties of helical polymers do not always align with the sum of the local contributions of their unit cells. This study investigates the discrepancy in optical rotatory strength between local and global structures using a right‐handed helical polyacetylene model. The chirality is examined through density functional theory (DFT) calculations. The analysis reveals that, at higher degrees...
Propranolol is currently considered as an emerging contaminant in water bodies. In this study, R‐ and S‐propranolol were determined in river samples by electrokinetic chromatography (EKC) using nanodiamonds (NDs) and human serum albumin (HSA) as a pseudo‐stationary phase in order to achieve enantioseparation. Previously, river samples were preconcentrated using a column filled with Amberlite® IR‐120...
For the synthesis and development of pharmaceuticals, chirality is an important structural component. Chiral heterocyclic compounds have annoyed the interest of synthetic chemists who are working to create useful and efficient techniques for these molecules. As indicated by the expanding number of chiral drugs created in the last two decades, the link between chirality and pharmacological activity...
Chiral pesticides have the special chiral structures, so enantioselective biological effects are usually observed in living organisms. Current study used paclobutrazol as a case study and explored the enantioselective degradation and oxidative stress effect on wheat. The results demonstrated that the degradation of R‐paclobutrazol was faster than S‐paclobutrazol significantly and improved the content...
Herein, the synthesis of two chiral NPBIs, (S)‐1 and (R)‐1, is reported and their self‐assembling features investigated. The reported NPBIs form chiral supramolecular polymers with a rich dichroic pattern by the π‐stacking of the aromatic backbones and the formation of an array of H‐bonds between the amide functional groups. Furthermore, the peripheral 3,4,5‐trialkoxy benzamide groups can form seven‐membered...
In this study, lipase‐catalyzed resolution of N‐acetyl‐DL‐methionine methyl ester (N‐Ac‐DL‐MetOMe) was evaluated. A lipase from Brucella thiophenivorans was prone to exhibit high activity and excellent enantioselectivity toward N‐Ac‐DL‐MetOMe to produce the key chiral intermediate N‐acetyl‐L‐methionine methyl ester (N‐Ac‐L‐MetOMe). The results showed that the enzymatic reaction was carried out in...
The R,S‐enantiomer impurity and diastereomer impurities (S,S‐isomer and R,R‐isomer) of the solifenacin (S,R‐enantiomer) were effectively separated and quantified simultaneously utilizing normal‐phase high‐performance liquid chromatography with a chiral stationary phase consisting of amylose tris (3,5‐dimethylphenylcarbamate) coated on silica‐gel (Chiralpak, AD‐H). The enantiomeric and stereo‐selective...
First antibiotic in the oxazolidinone class, linezolid fights gram‐positive multiresistant bacteria by inhibiting protein synthesis through its interaction with the 50S subunit of the functional bacterial ribosome. For its antimicrobial action, it is necessary that its chiral carbon located in the oxazolidinone ring is in the S‐conformation. Computational calculation at time‐dependent density functional...