The regulation of the concentration of a wide range of small molecules is ubiquitous in biological systems to adapt to the continuous changes in the environmental conditions. The cover artwork illustrates the opportunity to tune a host concentration in aqueous media in an orchestrated manner by controlling the partial collapse of a colored host–guest synthetic polymeric system featuring both thermo‐ and pH responsiveness. This colored supramolecular assembly is one of the first synthetic systems providing control over the concentration of a small molecule, providing great potential as both T and pH chromic materials and as a basis to develop more complex systems with molecular communication. More information can be found in the Full Paper by H. Guo, R. Hoogenboom, P. Woisel, et al. on page 1292.