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Objective
Serum sex steroid concentrations may alter body composition and glucose homoeostasis in men in a dose‐response manner. We evaluated these end‐points in healthy men rendered medically castrate through use of a gonadotrophin‐releasing hormone antagonist (acyline) with incremental doses of exogenous testosterone (T) gel.
Design
Subjects (n=6‐9 per group) were randomly assigned to injections...
Objective
Recent evidence suggests that androgens either directly or via aromatisation to oestradiol may regulate telomere length, hence providing a mechanism whereby reproductive steroids are linked to biological ageing in men. Using men with prostate cancer initiating androgen deprivation therapy (ADT), we tested the hypothesis that severe sex steroid deprivation would accelerate telomere shortening...
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