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The transcription factor Friend leukaemia virus integration 1 (Fli‐1) is implicated in the pathogenesis of systemic lupus erythematosus in both human patients and murine models of lupus. Murphy Roths large (MRL)/lpr mice and New Zealand mixed (NZM)2410 mice, murine models of lupus, with decreased expression of Fli‐1 had significantly prolonged survival and reduced nephritis. Lupus nephritis is a major...
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