Sweeping changes in the world of work are transforming the very fabric of career counseling practice as clients cope increasingly with work uncertainty, including unemployment, underemployment, and precarious work. The authors describe how relational perspectives (Blustein, 2011; Flum 2015; Richardson, 2012; Schultheiss, 2003) can be infused in career counseling, with a focus on the concerns of an increasingly stressed and anxious client population. To provide a framework for the application of relational perspectives, the authors integrate and present existing relational theories and frameworks in 4 tenets that have particular relevance for career counseling practice. An in‐depth case analysis is provided to illustrate how relational perspectives can be integrated in working with clients experiencing uncertain work and associated relational challenges.