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The receptor activator of NF‐κB ligand (RANKL)/osteoprotegerin (OPG) system is a well‐known key factor in osteoclast differentiation, and osteoblastic lineage cells are the major sources of RANKL and OPG in local bone tissue. Recently, a new molecule from the interleukin (IL)‐1 family, IL‐33, was identified. Here, we report the possible involvement of IL‐33 in RANKL and OPG expression, and the signaling...
Osteoclast differentiation/activation is involved in orthodontic tooth movement at the compression sites of the alveolar bone. RANKL, a member of the TNF family expressed in osteoblasts, binds to RANK, a member of the TNF receptor family expressed on preosteoclasts, resulting in differentiation of preosteoclasts into mature osteoclasts. Several members of the TNF family, such as TNF and Fas ligand,...
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