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Embryonic stem (ES) cells are derived from the inner cell mass of blastocysts and have a pluripotency to differentiate into a variety of cell types. ES cells have high resistance to environmental stress compared to functional cells, which can undergo apoptosis when stressed. We have investigated whether ES cells have resistance to multiple types of stress or selective stress. Phytosphingosine (PHS)...
Microtubule interfering agents (MIAs), that can stabilise or depolymerise microtubules, are an important class of cancer chemotherapeutic drugs. They can lead to mitotic arrest and subsequent apoptosis. We demonstrate that cell cycle‐dependent kinase 1 (CDK1) is important in switching cells from mitotic arrest to apoptosis during MIAs treatment. Overexpression of non‐degradable cyclin B1 sustained...
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