Front Cover. As reported by Yanyan Sun et al. in their full paper at https://doi.org/10.1002/cbdv.201800373, a series of novel platinum‐based complexes with 1,10‐phenanthroline as carrier ligands and alkoxyacetate anions as leaving groups were prepared and spectrally characterized. The water solubility and cytotoxicity of resulting complexes has been greatly improved by the replacement of anionic ligands in the precursor Pt(phen)Cl2 with alkoxyacetate anions. The in vitro cytotoxicity study by WST‐8 assay revealed that complexes 1–3, especially complex 1, showed considerable cytotoxicity against four tested tumor cell lines. Flow cytometry assay and agarose gel electrophoresis have been applied to explore the mechanism of action of platinum complexes to induce the death of tumor cells. Consequently, complex 1 with both good aqueous solubility and high in vitro cytotoxicity can be further studied as a potential antitumor candidate.