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Laulimalide (LAU) and Peloruside A (PLA) are non‐taxane microtubule stabilizing agents with promising antimitotic properties. These ligands promote the assembly of microtubules (MTs) by targeting a unique binding site on β‐tubulin. The X‐ray structure for LAU/PLA‐tubulin association was recently elucidated, but little information is available regarding the role of these ligands as modulators of interdimeric...
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