Patients with malignancy often require palliative dental care because of neglect, complications of the disease, or complications from the treatment of the disease. Sedation or general anesthesia can serve as an appropriate way to keep patients with cancer comfortable during a dental procedure. The extensive variety of cancers can compromise every major organ system. Common therapies for the management of cancer include chemotherapy, surgery, and radiation or often a combination therapy of the three. Vascular access can be difficult in patients with cancer, and special consideration must be given to the location of the intravenous catheter. Adverse pulmonary reactions such as acute non‐cardiogenic pulmonary edema are likely to occur in 5‐10% of patients undergoing chemotherapy. Kidney dysfunction can be a direct complication from tumor invasion or can be a result of chemotherapy. A comprehensive patient assessment is crucial to understand critical anesthesia considerations.