This chapter provides few guidelines on setting up a practice laboratory for veterinarians predominantly in cattle practice. It provides an overview for the practitioner, with some practical information about the practice laboratory that is hard to find in standard texts. The chapter talks about tests and techniques that may be useful in clinical pathology; microbiology and parasitology; the type of equipment required; and, finally, some suggestions about planning the practice laboratory. To calculate the speed (RPM) of the centrifuge for any particular fluid, we need to know the radius of the centrifuge, and the recommended RCF (g) and time spun for that fluid. Decision on which tests the clinic will perform varies from clinic to clinic, and will depend on the mix of clients seen, the expertise/interests of the clinic and the cost/benefit analysis.