This chapter presents an overview of Herpes viral ocular disease that is highly prevalent, resulting predominantly from animal‐to‐animal contact, frequently via aerosolization of sneezed particles. Affected animals may display a range of symptoms including sneezing, coughing, nasal discharge, pyrexia, inappetance, lethargy, conjunctivitis, chemosis, keratitis, and/or secondary corneal ulceration. Feline patients may additionally be infected with secondary pathogens including <i>Calicivirus</i>, <i>Chlamydophila felis</i>, <i>mycoplasma sp </i>and/or bacterial pathogens. Herpes viral disease (CHV‐1) should additionally be considered when investigating similar symptoms in canine patients. Accurate testing for the presence of FHV‐1 and its correlation with ophthalmic disease is challenging; however, polymerase chain reaction assays, based on tissue samples, are currently considered most reliable. Ultimately, healthy cats recover spontaneously from outbreaks over the course of several weeks; however, treatment is frequently indicated. Topical and/or systemic antiviral agents may be administered, including trifluorothymidine, idoxuridine, cidofovir, and ganciclovir and/or famciclovir.