This chapter presents an overview of symblepharon that results from loss of epithelial continuity, most commonly arising secondary to feline herpes viral disease but potentially arising secondary to any severe feline or canine conjunctival inflammation. The diagnosis of symblepharon is made based on clinical findings. Treatment comprises addressing conjunctival inflammation as well as underlying viral and/or bacterial disease. Surgical resection of conjunctival adhesions is relatively straightforward; however, the tendency for the aggressive reformation of these adhesions is extremely high. The potential benefits of surgical intervention should consequently be carefully considered before proceeding. Surgery should not be undertaken in actively inflamed or infected eyes. The use of silicone surgical barriers to prevent re‐adhesion before re‐epithelialization as well as the judicious use of antimicrobial and/or anti inflammatory agents may help maximize long‐term success.