Premenstrual syndrome (PMS) is a combination of emotional, behavioral, and physical symptoms that occur in the premenstrual or luteal phase of the menstrual cycle. Approximately 5% of women with the severest form of PMS usually have symptoms that meet the diagnostic criteria for Premenstrual Dysphoric Disorder (PMDD). Women with severe PMS and PMDD have reported disruption in their social relationships, parenting roles, and work productivity as well as increased healthcare utilization. Premenstrual symptoms have been reported in women from menarche through perimenopause. PMS has been reported to be more common in women who assign negative attributions to premenstrual symptoms, have poor coping strategies and problem‐solving abilities, and feel their symptoms are not in their control. One of the unique aspects of treating women with severe PMS and PMDD is that symptoms, though cyclical, may be present for 40 years of a woman's life.