Randomized control trials (RCTs) are prospectively designed studies that compare the effect of an intervention against a control group. By reducing confounding, this powerful tool provides better rationale for causality than observational design. The phases of a clinical trial include planning, preparatory, recruitment, patient follow‐up, termination, and analysis. Important components of an RCT include choosing the intervention and controls, selecting outcomes, measuring baseline variables, participant selection, randomization, blinding, and funding. Ethical considerations include approval from the Institutional Review Board (IRB) and obtaining informed consent if the study design allows for this.