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Refocusing of B‐cell responses can be achieved by preserving the overall fold of the antigen structure but selectively mutating the undesired antigenic sites with additional N‐linked glycosylation motifs for glycan masking the vaccine antigen. We previously reported that glycan‐masking recombinant H5 hemagglutinin (rH5HA) antigens on residues 83, 127, and 138 (g127 + g138 or g83 + g127 + 138 rH5HA)...
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