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Multiple comparison procedures combined with modeling techniques (MCP‐Mod) (Bretz et al., 2005) is an efficient and robust statistical methodology for the model‐based design and analysis of dose‐finding studies with an unknown dose–response model. With this approach, multiple comparison methods are used to identify statistically significant contrasts corresponding to a set of candidate dose–response...
Conventionally, evaluation of a new drug, A, is done in three phases. Phase I is based on toxicity to determine a “maximum tolerable dose” (MTD) of A, phase II is conducted to decide whether A at the MTD is promising in terms of response probability, and if so a large randomized phase III trial is conducted to compare A to a control treatment, usually based on survival time or progression free...
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