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Gut dysbiosis is an important modifier of pathologies including cardiovascular disease but our understanding of the role of individual microbes is limited. Here, we have used transplantation of mouse microbiota into microbiota‐deficient zebrafish larvae to study the interaction between members of a mammalian high fat diet‐associated gut microbiota with a lipid rich diet challenge in a tractable model...
Aging induces significant shifts in the composition of gut microbiota associated with decreased microbial diversity. Age‐related changes in gut microbiota include a loss of commensals and an increase in disease‐associated pathobionts. These alterations are accelerated by lifestyle factors, such as poor nutritional habits, physical inactivity, and medications. Given that diet is one of the main drivers...
Histidine metabolism is a key pathway physiologically involved in satiety, recognition memory, skin, and neural protection and allergic diseases. Microbiologically‐produced imidazole propionate induces type II diabetes and interferes with glucose lowering drugs. Despite their determinant health implications, no single method simultaneously assesses histidine metabolites in urine, feces, and microbiota...
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