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AimsEribulin mesilate is an inhibitor of microtubule dynamics that is approved for the treatment of late‐stage metastatic breast cancer. Neutropenia is one of the major dose‐limiting adverse effects of eribulin. The objective of this analysis was to develop a population pharmacokinetic–pharmacodynamic model for eribulin‐associated neutropenia.
MethodsA combined data set of 12 phase I, II and III...
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