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Prp28 (pre‐mRNA‐splicing ATP‐dependent RNA helicase 28) is a spliceosomal DEAD‐box helicase which is involved in two steps of spliceosome assembly. It is required for the formation of commitment complex 2 in an ATP‐independent manner as well as for the formation of the pre‐catalytic spliceosome, which in contrast is ATP‐dependent. During the latter step, Prp28 is crucial for the integration of the...
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